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Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction

BACKGROUND: The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study. MATERIALS AND METHODS: The single nucleotide polymorphisms (SNP...

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Autores principales: Xiong, Yang, Zhong, Xin, Zhang, Fuxun, Wang, Wei, Zhang, Yangchang, Wu, Changjing, Qin, Feng, Yuan, Jiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174907/
https://www.ncbi.nlm.nih.gov/pubmed/35692403
http://dx.doi.org/10.3389/fendo.2022.896369
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author Xiong, Yang
Zhong, Xin
Zhang, Fuxun
Wang, Wei
Zhang, Yangchang
Wu, Changjing
Qin, Feng
Yuan, Jiuhong
author_facet Xiong, Yang
Zhong, Xin
Zhang, Fuxun
Wang, Wei
Zhang, Yangchang
Wu, Changjing
Qin, Feng
Yuan, Jiuhong
author_sort Xiong, Yang
collection PubMed
description BACKGROUND: The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study. MATERIALS AND METHODS: The single nucleotide polymorphisms (SNPs) associated with snoring were retrieved from the UK biobank cohort with 314,449 participants (117,812 cases and 196,637 controls). The summary statistics of ED were obtained from the European ancestry with 223,805 subjects (6,175 cases and 217,630 controls). Single-variable Mendelian randomization (MR) and multivariable MR were used to assess the causal relationship between snoring and ED. RESULTS: Snoring increases the risk of ED (Odds ratio [OR] = 3.45, 95% confidence interval [CI] = 1.68 - 7.09, P < 0.001) in the inverse variance weighting estimator. In sensitivity analyses, the ORs for the weighted median, MR robust adjusted profile score, and MR Pleiotropy Residual Sum and Outlier approach, MR-Egger, and maximum likelihood method are 5.70 (95% CI = 1.19 - 27.21, P < 0.05), 3.14 (95% CI = 1.01 - 9.72, P < 0.05), 3.11 (95% CI = 1.63 - 5.91, P < 0.01), 1.23 (95% CI = 0.01 – 679.73, P > 0.05), and 3.59 (95% CI = 1.07 – 12.00, P < 0.05), respectively. No heterogeneity and pleiotropy are observed (P for MR-Egger intercept = 0.748; P for global test = 0.997; P for Cochran’s Q statistics > 0.05). After adjusting for total cholesterol, triglyceride, low-density lipoprotein, and cigarette consumption, the ORs for ED are 5.75 (95% CI = 1.80 - 18.34, P < 0.01), 4.16 (95% CI = 1.10 - 15.81, P < 0.05), 5.50 (95% CI = 1.62 - 18.69, P < 0.01), and 2.74 (95% CI = 1.06 - 7.10, P < 0.05), respectively. CONCLUSION: This study provides genetic evidence supporting the causal role of snoring in ED.
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spelling pubmed-91749072022-06-09 Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction Xiong, Yang Zhong, Xin Zhang, Fuxun Wang, Wei Zhang, Yangchang Wu, Changjing Qin, Feng Yuan, Jiuhong Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study. MATERIALS AND METHODS: The single nucleotide polymorphisms (SNPs) associated with snoring were retrieved from the UK biobank cohort with 314,449 participants (117,812 cases and 196,637 controls). The summary statistics of ED were obtained from the European ancestry with 223,805 subjects (6,175 cases and 217,630 controls). Single-variable Mendelian randomization (MR) and multivariable MR were used to assess the causal relationship between snoring and ED. RESULTS: Snoring increases the risk of ED (Odds ratio [OR] = 3.45, 95% confidence interval [CI] = 1.68 - 7.09, P < 0.001) in the inverse variance weighting estimator. In sensitivity analyses, the ORs for the weighted median, MR robust adjusted profile score, and MR Pleiotropy Residual Sum and Outlier approach, MR-Egger, and maximum likelihood method are 5.70 (95% CI = 1.19 - 27.21, P < 0.05), 3.14 (95% CI = 1.01 - 9.72, P < 0.05), 3.11 (95% CI = 1.63 - 5.91, P < 0.01), 1.23 (95% CI = 0.01 – 679.73, P > 0.05), and 3.59 (95% CI = 1.07 – 12.00, P < 0.05), respectively. No heterogeneity and pleiotropy are observed (P for MR-Egger intercept = 0.748; P for global test = 0.997; P for Cochran’s Q statistics > 0.05). After adjusting for total cholesterol, triglyceride, low-density lipoprotein, and cigarette consumption, the ORs for ED are 5.75 (95% CI = 1.80 - 18.34, P < 0.01), 4.16 (95% CI = 1.10 - 15.81, P < 0.05), 5.50 (95% CI = 1.62 - 18.69, P < 0.01), and 2.74 (95% CI = 1.06 - 7.10, P < 0.05), respectively. CONCLUSION: This study provides genetic evidence supporting the causal role of snoring in ED. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174907/ /pubmed/35692403 http://dx.doi.org/10.3389/fendo.2022.896369 Text en Copyright © 2022 Xiong, Zhong, Zhang, Wang, Zhang, Wu, Qin and Yuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Xiong, Yang
Zhong, Xin
Zhang, Fuxun
Wang, Wei
Zhang, Yangchang
Wu, Changjing
Qin, Feng
Yuan, Jiuhong
Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
title Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
title_full Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
title_fullStr Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
title_full_unstemmed Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
title_short Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
title_sort genetic evidence supporting a causal role of snoring in erectile dysfunction
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174907/
https://www.ncbi.nlm.nih.gov/pubmed/35692403
http://dx.doi.org/10.3389/fendo.2022.896369
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