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The Role of SIRT3 in the Osteoporosis

SIRT3 is an NAD(+)-dependent deacetylase in the mitochondria with an extensive ability to regulate mitochondrial morphology and function. It has been reported that SIRT3 participates in the occurrence and development of many aging-related diseases. Osteoporosis is a common aging-related disease char...

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Detalles Bibliográficos
Autores principales: Hu, Siwang, Wang, Shuangshuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175005/
https://www.ncbi.nlm.nih.gov/pubmed/35692409
http://dx.doi.org/10.3389/fendo.2022.893678
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author Hu, Siwang
Wang, Shuangshuang
author_facet Hu, Siwang
Wang, Shuangshuang
author_sort Hu, Siwang
collection PubMed
description SIRT3 is an NAD(+)-dependent deacetylase in the mitochondria with an extensive ability to regulate mitochondrial morphology and function. It has been reported that SIRT3 participates in the occurrence and development of many aging-related diseases. Osteoporosis is a common aging-related disease characterized by decreased bone mass and fragility fractures, which has caused a huge burden on society. Current research shows that SIRT3 is involved in the physiological processes of senescence of bone marrow mesenchymal stem cells (BMSCs), differentiation of BMSCs and osteoclasts. However, the specific effects and mechanisms of SIRT3 in osteoporosis are not clear. In the current review, we elaborated on the physiological functions of SIRT3, the cell types involved in bone remodeling, and the role of SIRT3 in osteoporosis. Furthermore, it also provided a theoretical basis for SIRT3 as a therapeutic target for osteoporosis.
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spelling pubmed-91750052022-06-09 The Role of SIRT3 in the Osteoporosis Hu, Siwang Wang, Shuangshuang Front Endocrinol (Lausanne) Endocrinology SIRT3 is an NAD(+)-dependent deacetylase in the mitochondria with an extensive ability to regulate mitochondrial morphology and function. It has been reported that SIRT3 participates in the occurrence and development of many aging-related diseases. Osteoporosis is a common aging-related disease characterized by decreased bone mass and fragility fractures, which has caused a huge burden on society. Current research shows that SIRT3 is involved in the physiological processes of senescence of bone marrow mesenchymal stem cells (BMSCs), differentiation of BMSCs and osteoclasts. However, the specific effects and mechanisms of SIRT3 in osteoporosis are not clear. In the current review, we elaborated on the physiological functions of SIRT3, the cell types involved in bone remodeling, and the role of SIRT3 in osteoporosis. Furthermore, it also provided a theoretical basis for SIRT3 as a therapeutic target for osteoporosis. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9175005/ /pubmed/35692409 http://dx.doi.org/10.3389/fendo.2022.893678 Text en Copyright © 2022 Hu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hu, Siwang
Wang, Shuangshuang
The Role of SIRT3 in the Osteoporosis
title The Role of SIRT3 in the Osteoporosis
title_full The Role of SIRT3 in the Osteoporosis
title_fullStr The Role of SIRT3 in the Osteoporosis
title_full_unstemmed The Role of SIRT3 in the Osteoporosis
title_short The Role of SIRT3 in the Osteoporosis
title_sort role of sirt3 in the osteoporosis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175005/
https://www.ncbi.nlm.nih.gov/pubmed/35692409
http://dx.doi.org/10.3389/fendo.2022.893678
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