Cargando…

Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy

AIMS: This study aimed to evaluate the causal association between obesity and hypertension disorders in pregnancy. METHODS: Two-sample Mendelian randomization (MR) study was conducted based on the data obtained from the GIANT (n = 98,697 participants) consortium and FinnGen (n = 96,449 participants)...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wenting, Tan, Jiang-Shan, Hua, Lu, Zhu, Shengsong, Lin, Hongyun, Wu, Yan, Liu, Jinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175023/
https://www.ncbi.nlm.nih.gov/pubmed/35694671
http://dx.doi.org/10.3389/fcvm.2022.888982
_version_ 1784722365482008576
author Wang, Wenting
Tan, Jiang-Shan
Hua, Lu
Zhu, Shengsong
Lin, Hongyun
Wu, Yan
Liu, Jinping
author_facet Wang, Wenting
Tan, Jiang-Shan
Hua, Lu
Zhu, Shengsong
Lin, Hongyun
Wu, Yan
Liu, Jinping
author_sort Wang, Wenting
collection PubMed
description AIMS: This study aimed to evaluate the causal association between obesity and hypertension disorders in pregnancy. METHODS: Two-sample Mendelian randomization (MR) study was conducted based on the data obtained from the GIANT (n = 98,697 participants) consortium and FinnGen (n = 96,449 participants) consortium to determine the causal effect of obesity on the risk of hypertension disorders in pregnancy. Based on a genome-wide significance, 14 single-nucleotide polymorphisms (SNPs) associated with obesity-related databases were used as instrumental variables. The random-effects inverse-variance weighted (IVW) method was adopted as the main analysis with a supplemented sensitive analysis of the MR-Egger and weighted median approaches. RESULTS: All three MR methods showed that genetically predicted obesity causally increased the risk of hypertension disorders in pregnancy. IVW analysis provided obesity as a risk factor for hypertension disorders in pregnancy with an odds ratio (OR) of 1.39 [95% confidence interval (CI) 1.21–1.59; P = 2.46 × 10(−6)]. Weighted median and MR Egger regression also showed directionally similar results [weighted median OR = 1.49 (95% CI, 1.24–1.79), P = 2.45 × 10(−5); MR-Egger OR = 1.95 (95% CI, 1.35–2.82), P = 3.84 × 10(−3)]. No directional pleiotropic effects were found between obesity and hypertension disorders in pregnancy with both MR-Egger intercepts and funnel plots. CONCLUSIONS: Our findings provided directed evidence that obesity was causally associated with a higher risk of hypertension disorders in pregnancy. Taking measures to reduce the proportion of obesity may help reduce the incidence of hypertension disorders in pregnancy.
format Online
Article
Text
id pubmed-9175023
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91750232022-06-09 Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy Wang, Wenting Tan, Jiang-Shan Hua, Lu Zhu, Shengsong Lin, Hongyun Wu, Yan Liu, Jinping Front Cardiovasc Med Cardiovascular Medicine AIMS: This study aimed to evaluate the causal association between obesity and hypertension disorders in pregnancy. METHODS: Two-sample Mendelian randomization (MR) study was conducted based on the data obtained from the GIANT (n = 98,697 participants) consortium and FinnGen (n = 96,449 participants) consortium to determine the causal effect of obesity on the risk of hypertension disorders in pregnancy. Based on a genome-wide significance, 14 single-nucleotide polymorphisms (SNPs) associated with obesity-related databases were used as instrumental variables. The random-effects inverse-variance weighted (IVW) method was adopted as the main analysis with a supplemented sensitive analysis of the MR-Egger and weighted median approaches. RESULTS: All three MR methods showed that genetically predicted obesity causally increased the risk of hypertension disorders in pregnancy. IVW analysis provided obesity as a risk factor for hypertension disorders in pregnancy with an odds ratio (OR) of 1.39 [95% confidence interval (CI) 1.21–1.59; P = 2.46 × 10(−6)]. Weighted median and MR Egger regression also showed directionally similar results [weighted median OR = 1.49 (95% CI, 1.24–1.79), P = 2.45 × 10(−5); MR-Egger OR = 1.95 (95% CI, 1.35–2.82), P = 3.84 × 10(−3)]. No directional pleiotropic effects were found between obesity and hypertension disorders in pregnancy with both MR-Egger intercepts and funnel plots. CONCLUSIONS: Our findings provided directed evidence that obesity was causally associated with a higher risk of hypertension disorders in pregnancy. Taking measures to reduce the proportion of obesity may help reduce the incidence of hypertension disorders in pregnancy. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9175023/ /pubmed/35694671 http://dx.doi.org/10.3389/fcvm.2022.888982 Text en Copyright © 2022 Wang, Tan, Hua, Zhu, Lin, Wu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wang, Wenting
Tan, Jiang-Shan
Hua, Lu
Zhu, Shengsong
Lin, Hongyun
Wu, Yan
Liu, Jinping
Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
title Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
title_full Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
title_fullStr Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
title_full_unstemmed Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
title_short Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
title_sort genetically predicted obesity causally increased the risk of hypertension disorders in pregnancy
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175023/
https://www.ncbi.nlm.nih.gov/pubmed/35694671
http://dx.doi.org/10.3389/fcvm.2022.888982
work_keys_str_mv AT wangwenting geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy
AT tanjiangshan geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy
AT hualu geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy
AT zhushengsong geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy
AT linhongyun geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy
AT wuyan geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy
AT liujinping geneticallypredictedobesitycausallyincreasedtheriskofhypertensiondisordersinpregnancy