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Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2

Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration. The aim of this work was to 1) simultaneously characterise the pharmacokinetic...

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Detalles Bibliográficos
Autores principales:	Ren, Hong-can, Sun, Jian-guo, A, Ji-ye, Gu, Sheng-hua, Shi, Jian, Shao, Feng, Ai, Hua, Zhang, Jing-wei, Peng, Ying, Yan, Bei, Huang, Qing, Liu, Lin-sheng, Sai, Yang, Wang, Guang-ji, Yang, Cheng-guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175024/ https://www.ncbi.nlm.nih.gov/pubmed/35694247 http://dx.doi.org/10.3389/fphar.2022.804377

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