Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis

[Image: see text] The disruption of polynucleotide kinase/phosphatase (PNKP) in colorectal cancer (CRC) cells deficient in phosphatase and tensin homolog (PTEN) is expected to lead to the loss of cell viability by a process known as synthetic lethality. In previous studies, we have reported on the e...

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Detalles Bibliográficos
Autores principales: de Paiva, Igor Moura, Vakili, Mohammad Reza, Soleimani, Amir Hasan, Tabatabaei Dakhili, Seyed Amirhossein, Munira, Sirazum, Paladino, Marco, Martin, Gary, Jirik, Frank R., Hall, Dennis G., Weinfeld, Michael, Lavasanifar, Afsaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175178/
https://www.ncbi.nlm.nih.gov/pubmed/35271294
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00918

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