Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expression. We sought to link p16-expression with a diagnosis o...

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Detalles Bibliográficos
Autores principales: Keow, Jonathan, Cecchini, Matthew J., Jayawardena, Nathashi, Zompatori, Maurizio, Joseph, Mariamma G., Mura, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175499/
https://www.ncbi.nlm.nih.gov/pubmed/35672770
http://dx.doi.org/10.1186/s12931-022-02067-w

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