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A suppressor of dioxygenase inhibition in a yeast model of SDH deficiency

A fascinating class of familial paraganglioma (PGL) neuroendocrine tumors is driven by the loss of the tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) resulting in succinate accumulation as an oncometabolite and other metabolic derangements. Here, we exploit a Saccharomyces cerev...

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Detalles Bibliográficos
Autores principales:	Beimers, William, Braun, Megan, Schwinefus, Kaleb, Pearson, Keenan, Wilbanks, Brandon, Maher, Louis James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175558/ https://www.ncbi.nlm.nih.gov/pubmed/35315791 http://dx.doi.org/10.1530/ERC-21-0349

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