Cargando…

Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts

OBJECTIVE: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. DESIGN: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-s...

Descripción completa

Detalles Bibliográficos
Autores principales: Vogt, Elinor Chelsom, Real, Francisco Gómez, Husebye, Eystein Sverre, Björnsdottir, Sigridur, Benediktsdottir, Bryndis, Bertelsen, Randi Jacobsen, Demoly, Pascal, Franklin, Karl Anders, de Aja Gallastegui, Leire Sainz, González, Francisco Javier Callejas, Heinrich, Joachim, Holm, Mathias, Jogi, Nils Oscar, Leynaert, Benedicte, Lindberg, Eva, Malinovschi, Andrei, Martínez-Moratalla, Jesús, Mayoral, Raúl Godoy, Oudin, Anna, Pereira-Vega, Antonio, Semjen, Chantal Raherison, Schlünssen, Vivi, Triebner, Kai, Øksnes, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175594/
https://www.ncbi.nlm.nih.gov/pubmed/35521804
http://dx.doi.org/10.1530/EC-22-0024
_version_ 1784722486447833088
author Vogt, Elinor Chelsom
Real, Francisco Gómez
Husebye, Eystein Sverre
Björnsdottir, Sigridur
Benediktsdottir, Bryndis
Bertelsen, Randi Jacobsen
Demoly, Pascal
Franklin, Karl Anders
de Aja Gallastegui, Leire Sainz
González, Francisco Javier Callejas
Heinrich, Joachim
Holm, Mathias
Jogi, Nils Oscar
Leynaert, Benedicte
Lindberg, Eva
Malinovschi, Andrei
Martínez-Moratalla, Jesús
Mayoral, Raúl Godoy
Oudin, Anna
Pereira-Vega, Antonio
Semjen, Chantal Raherison
Schlünssen, Vivi
Triebner, Kai
Øksnes, Marianne
author_facet Vogt, Elinor Chelsom
Real, Francisco Gómez
Husebye, Eystein Sverre
Björnsdottir, Sigridur
Benediktsdottir, Bryndis
Bertelsen, Randi Jacobsen
Demoly, Pascal
Franklin, Karl Anders
de Aja Gallastegui, Leire Sainz
González, Francisco Javier Callejas
Heinrich, Joachim
Holm, Mathias
Jogi, Nils Oscar
Leynaert, Benedicte
Lindberg, Eva
Malinovschi, Andrei
Martínez-Moratalla, Jesús
Mayoral, Raúl Godoy
Oudin, Anna
Pereira-Vega, Antonio
Semjen, Chantal Raherison
Schlünssen, Vivi
Triebner, Kai
Øksnes, Marianne
author_sort Vogt, Elinor Chelsom
collection PubMed
description OBJECTIVE: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. DESIGN: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women. METHODS: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI. RESULTS: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63–3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin. CONCLUSION: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.
format Online
Article
Text
id pubmed-9175594
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-91755942022-06-14 Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts Vogt, Elinor Chelsom Real, Francisco Gómez Husebye, Eystein Sverre Björnsdottir, Sigridur Benediktsdottir, Bryndis Bertelsen, Randi Jacobsen Demoly, Pascal Franklin, Karl Anders de Aja Gallastegui, Leire Sainz González, Francisco Javier Callejas Heinrich, Joachim Holm, Mathias Jogi, Nils Oscar Leynaert, Benedicte Lindberg, Eva Malinovschi, Andrei Martínez-Moratalla, Jesús Mayoral, Raúl Godoy Oudin, Anna Pereira-Vega, Antonio Semjen, Chantal Raherison Schlünssen, Vivi Triebner, Kai Øksnes, Marianne Endocr Connect Research OBJECTIVE: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. DESIGN: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women. METHODS: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI. RESULTS: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63–3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin. CONCLUSION: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies. Bioscientifica Ltd 2022-04-22 /pmc/articles/PMC9175594/ /pubmed/35521804 http://dx.doi.org/10.1530/EC-22-0024 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research
Vogt, Elinor Chelsom
Real, Francisco Gómez
Husebye, Eystein Sverre
Björnsdottir, Sigridur
Benediktsdottir, Bryndis
Bertelsen, Randi Jacobsen
Demoly, Pascal
Franklin, Karl Anders
de Aja Gallastegui, Leire Sainz
González, Francisco Javier Callejas
Heinrich, Joachim
Holm, Mathias
Jogi, Nils Oscar
Leynaert, Benedicte
Lindberg, Eva
Malinovschi, Andrei
Martínez-Moratalla, Jesús
Mayoral, Raúl Godoy
Oudin, Anna
Pereira-Vega, Antonio
Semjen, Chantal Raherison
Schlünssen, Vivi
Triebner, Kai
Øksnes, Marianne
Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
title Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
title_full Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
title_fullStr Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
title_full_unstemmed Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
title_short Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
title_sort premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175594/
https://www.ncbi.nlm.nih.gov/pubmed/35521804
http://dx.doi.org/10.1530/EC-22-0024
work_keys_str_mv AT vogtelinorchelsom prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT realfranciscogomez prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT husebyeeysteinsverre prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT bjornsdottirsigridur prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT benediktsdottirbryndis prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT bertelsenrandijacobsen prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT demolypascal prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT franklinkarlanders prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT deajagallasteguileiresainz prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT gonzalezfranciscojaviercallejas prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT heinrichjoachim prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT holmmathias prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT joginilsoscar prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT leynaertbenedicte prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT lindbergeva prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT malinovschiandrei prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT martinezmoratallajesus prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT mayoralraulgodoy prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT oudinanna prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT pereiravegaantonio prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT semjenchantalraherison prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT schlunssenvivi prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT triebnerkai prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts
AT øksnesmarianne prematuremenopauseandautoimmuneprimaryovarianinsufficiencyintwointernationalmulticentercohorts