Somatic Hypermutation and Framework Mutations of Variable Region Contribute to Anti-Zika Virus-Specific Monoclonal Antibody Binding and Function

Zika virus (ZIKV) is a global public health concern due to its ability to cause congenital Zika syndrome and lack of approved vaccine, therapeutic, or other control measures. We discovered eight novel rabbit monoclonal antibodies (MAbs) that bind to distinct ZIKV envelope protein epitopes. The major...

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Detalles Bibliográficos
Autores principales: Tsuji, Isamu, Vang, Fue, Dominguez, David, Karwal, Lovkesh, Sanjali, Ankita, Livengood, Jill A., Davidson, Edgar, Fouch, Mallorie E., Doranz, Benjamin J., Das, Subash C., Dean, Hansi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175631/
https://www.ncbi.nlm.nih.gov/pubmed/35575481
http://dx.doi.org/10.1128/jvi.00071-22

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