Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma

Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine‐rituximab. In this report, treatment with pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammato...

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Autores principales: Dufour, Inès, Duprez, Thierry, Wertz, Marie, Saussoy, Pascale, Ackermans, Nathalie, El Sankari, Souraya, van Pesch, Vincent, Van Den Neste, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175693/
https://www.ncbi.nlm.nih.gov/pubmed/35845001
http://dx.doi.org/10.1002/jha2.56
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author Dufour, Inès
Duprez, Thierry
Wertz, Marie
Saussoy, Pascale
Ackermans, Nathalie
El Sankari, Souraya
van Pesch, Vincent
Van Den Neste, Eric
author_facet Dufour, Inès
Duprez, Thierry
Wertz, Marie
Saussoy, Pascale
Ackermans, Nathalie
El Sankari, Souraya
van Pesch, Vincent
Van Den Neste, Eric
author_sort Dufour, Inès
collection PubMed
description Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine‐rituximab. In this report, treatment with pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammatory syndrome (IRIS), allowing complete clearance of the virus. These findings may further support the use of pembrolizumab in PML with special consideration for the potential occurrence of IRIS.
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spelling pubmed-91756932022-07-14 Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma Dufour, Inès Duprez, Thierry Wertz, Marie Saussoy, Pascale Ackermans, Nathalie El Sankari, Souraya van Pesch, Vincent Van Den Neste, Eric EJHaem Case Reports Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine‐rituximab. In this report, treatment with pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammatory syndrome (IRIS), allowing complete clearance of the virus. These findings may further support the use of pembrolizumab in PML with special consideration for the potential occurrence of IRIS. John Wiley and Sons Inc. 2020-10-23 /pmc/articles/PMC9175693/ /pubmed/35845001 http://dx.doi.org/10.1002/jha2.56 Text en © 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Dufour, Inès
Duprez, Thierry
Wertz, Marie
Saussoy, Pascale
Ackermans, Nathalie
El Sankari, Souraya
van Pesch, Vincent
Van Den Neste, Eric
Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
title Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
title_full Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
title_fullStr Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
title_full_unstemmed Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
title_short Improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
title_sort improvement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175693/
https://www.ncbi.nlm.nih.gov/pubmed/35845001
http://dx.doi.org/10.1002/jha2.56
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