Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10)

Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a...

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Detalles Bibliográficos
Autores principales: Horio, Tomohiro, Enomoto, Megumi, Watarai, Masaya, Nakano, Yuuta, Yamada, Saki, Matsumura, Saori, Kanasugi, Jo, Takasugi, Soichi, Nakamura, Ayano, Uchino, Kaori, Mizuno, Shohei, Murakami, Satsuki, Yamamoto, Hidesuke, Hanamura, Ichiro, Takami, Akiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175747/
https://www.ncbi.nlm.nih.gov/pubmed/35844998
http://dx.doi.org/10.1002/jha2.115
Descripción
Sumario:Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3‐year survival rate of 86%; in contrast, the remaining six cases had a 3‐year survival rate of 0% (P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis.

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