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Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10)
Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175747/ https://www.ncbi.nlm.nih.gov/pubmed/35844998 http://dx.doi.org/10.1002/jha2.115 |
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| author | Horio, Tomohiro Enomoto, Megumi Watarai, Masaya Nakano, Yuuta Yamada, Saki Matsumura, Saori Kanasugi, Jo Takasugi, Soichi Nakamura, Ayano Uchino, Kaori Mizuno, Shohei Murakami, Satsuki Yamamoto, Hidesuke Hanamura, Ichiro Takami, Akiyoshi |
| author_facet | Horio, Tomohiro Enomoto, Megumi Watarai, Masaya Nakano, Yuuta Yamada, Saki Matsumura, Saori Kanasugi, Jo Takasugi, Soichi Nakamura, Ayano Uchino, Kaori Mizuno, Shohei Murakami, Satsuki Yamamoto, Hidesuke Hanamura, Ichiro Takami, Akiyoshi |
| author_sort | Horio, Tomohiro |
| collection | PubMed |
| description | Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3‐year survival rate of 86%; in contrast, the remaining six cases had a 3‐year survival rate of 0% (P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis. |
| format | Online Article Text |
| id | pubmed-9175747 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91757472022-07-14 Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) Horio, Tomohiro Enomoto, Megumi Watarai, Masaya Nakano, Yuuta Yamada, Saki Matsumura, Saori Kanasugi, Jo Takasugi, Soichi Nakamura, Ayano Uchino, Kaori Mizuno, Shohei Murakami, Satsuki Yamamoto, Hidesuke Hanamura, Ichiro Takami, Akiyoshi EJHaem Short Reports Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3‐year survival rate of 86%; in contrast, the remaining six cases had a 3‐year survival rate of 0% (P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis. John Wiley and Sons Inc. 2020-10-08 /pmc/articles/PMC9175747/ /pubmed/35844998 http://dx.doi.org/10.1002/jha2.115 Text en © 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Short Reports Horio, Tomohiro Enomoto, Megumi Watarai, Masaya Nakano, Yuuta Yamada, Saki Matsumura, Saori Kanasugi, Jo Takasugi, Soichi Nakamura, Ayano Uchino, Kaori Mizuno, Shohei Murakami, Satsuki Yamamoto, Hidesuke Hanamura, Ichiro Takami, Akiyoshi Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| title | Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| title_full | Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| title_fullStr | Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| title_full_unstemmed | Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| title_short | Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| title_sort | favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10) |
| topic | Short Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175747/ https://www.ncbi.nlm.nih.gov/pubmed/35844998 http://dx.doi.org/10.1002/jha2.115 |
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