T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone

A 64‐year‐old man with angioimmunoblastic T‐cell lymphoma (AITL) subsequently developed diffuse large B‐cell lymphoma (DLBCL) and myelodysplastic syndrome (MDS). Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in TET2 and DNMT3...

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Autores principales: Yoshihara, Kyoko, Nannya, Yasuhito, Matsuda, Ikuo, Samori, Mami, Utsunomiya, Nobuto, Okada, Masaya, Hirota, Seiichi, Ogawa, Seishi, Yoshihara, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175790/
https://www.ncbi.nlm.nih.gov/pubmed/35846192
http://dx.doi.org/10.1002/jha2.354
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author Yoshihara, Kyoko
Nannya, Yasuhito
Matsuda, Ikuo
Samori, Mami
Utsunomiya, Nobuto
Okada, Masaya
Hirota, Seiichi
Ogawa, Seishi
Yoshihara, Satoshi
author_facet Yoshihara, Kyoko
Nannya, Yasuhito
Matsuda, Ikuo
Samori, Mami
Utsunomiya, Nobuto
Okada, Masaya
Hirota, Seiichi
Ogawa, Seishi
Yoshihara, Satoshi
author_sort Yoshihara, Kyoko
collection PubMed
description A 64‐year‐old man with angioimmunoblastic T‐cell lymphoma (AITL) subsequently developed diffuse large B‐cell lymphoma (DLBCL) and myelodysplastic syndrome (MDS). Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in TET2 and DNMT3A. In addition, the IDH2 mutation was observed in AITL, and TP53 mutation was observed in DLBCL and MDS. These findings illustrate the clonal relationship between AITL and DLBCL in addition to AITL and MDS, with the latter being increasingly reported. The present findings strongly support the theory of multistep and multilineage tumorigenesis from a common founder clone.
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spelling pubmed-91757902022-07-14 T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone Yoshihara, Kyoko Nannya, Yasuhito Matsuda, Ikuo Samori, Mami Utsunomiya, Nobuto Okada, Masaya Hirota, Seiichi Ogawa, Seishi Yoshihara, Satoshi EJHaem Case Reports A 64‐year‐old man with angioimmunoblastic T‐cell lymphoma (AITL) subsequently developed diffuse large B‐cell lymphoma (DLBCL) and myelodysplastic syndrome (MDS). Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in TET2 and DNMT3A. In addition, the IDH2 mutation was observed in AITL, and TP53 mutation was observed in DLBCL and MDS. These findings illustrate the clonal relationship between AITL and DLBCL in addition to AITL and MDS, with the latter being increasingly reported. The present findings strongly support the theory of multistep and multilineage tumorigenesis from a common founder clone. John Wiley and Sons Inc. 2021-12-03 /pmc/articles/PMC9175790/ /pubmed/35846192 http://dx.doi.org/10.1002/jha2.354 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Yoshihara, Kyoko
Nannya, Yasuhito
Matsuda, Ikuo
Samori, Mami
Utsunomiya, Nobuto
Okada, Masaya
Hirota, Seiichi
Ogawa, Seishi
Yoshihara, Satoshi
T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone
title T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone
title_full T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone
title_fullStr T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone
title_full_unstemmed T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone
title_short T‐cell lymphoma, B‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone
title_sort t‐cell lymphoma, b‐cell lymphoma, and myelodysplastic syndrome harboring common mutations: trilineage tumorigenesis from a common founder clone
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175790/
https://www.ncbi.nlm.nih.gov/pubmed/35846192
http://dx.doi.org/10.1002/jha2.354
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