The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease

This study was undertaken to identify baseline conditions and triggering factors for skeletal‐related events (SRE) in multiple myeloma (MM) patients treated with denosumab. During the median follow‐up of 17 months, SRE occurred in 6 out of 52 newly diagnosed patients and in 5 out of 23 relapsed/refr...

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Autores principales: Miki, Hirokazu, Nakamura, Shingen, Oura, Masahiro, Nakamura, Masafumi, Sumitani, Ryohei, Sogabe, Kimiko, Takahashi, Mamiko, Maruhashi, Tomoko, Harada, Takeshi, Fujii, Shiro, Hamano, Hirofumi, Kondo, Masateru, Okada, Naoto, Endo, Itsuro, Abe, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175803/
https://www.ncbi.nlm.nih.gov/pubmed/35846024
http://dx.doi.org/10.1002/jha2.402
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author Miki, Hirokazu
Nakamura, Shingen
Oura, Masahiro
Nakamura, Masafumi
Sumitani, Ryohei
Sogabe, Kimiko
Takahashi, Mamiko
Maruhashi, Tomoko
Harada, Takeshi
Fujii, Shiro
Hamano, Hirofumi
Kondo, Masateru
Okada, Naoto
Endo, Itsuro
Abe, Masahiro
author_facet Miki, Hirokazu
Nakamura, Shingen
Oura, Masahiro
Nakamura, Masafumi
Sumitani, Ryohei
Sogabe, Kimiko
Takahashi, Mamiko
Maruhashi, Tomoko
Harada, Takeshi
Fujii, Shiro
Hamano, Hirofumi
Kondo, Masateru
Okada, Naoto
Endo, Itsuro
Abe, Masahiro
author_sort Miki, Hirokazu
collection PubMed
description This study was undertaken to identify baseline conditions and triggering factors for skeletal‐related events (SRE) in multiple myeloma (MM) patients treated with denosumab. During the median follow‐up of 17 months, SRE occurred in 6 out of 52 newly diagnosed patients and in 5 out of 23 relapsed/refractory patients. Bone fractures occurred by falling down due to orthostatic hypotension and/or muscle weakness in three out of four cases with amyloid light‐chain (AL) amyloidosis. A loss of balance and falling down appear to be triggering factors for SRE, especially in frail MM patients with AL amyloidosis, indicating the importance of retaining physical functions to prevent SRE.
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spelling pubmed-91758032022-07-14 The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease Miki, Hirokazu Nakamura, Shingen Oura, Masahiro Nakamura, Masafumi Sumitani, Ryohei Sogabe, Kimiko Takahashi, Mamiko Maruhashi, Tomoko Harada, Takeshi Fujii, Shiro Hamano, Hirofumi Kondo, Masateru Okada, Naoto Endo, Itsuro Abe, Masahiro EJHaem Short Reports This study was undertaken to identify baseline conditions and triggering factors for skeletal‐related events (SRE) in multiple myeloma (MM) patients treated with denosumab. During the median follow‐up of 17 months, SRE occurred in 6 out of 52 newly diagnosed patients and in 5 out of 23 relapsed/refractory patients. Bone fractures occurred by falling down due to orthostatic hypotension and/or muscle weakness in three out of four cases with amyloid light‐chain (AL) amyloidosis. A loss of balance and falling down appear to be triggering factors for SRE, especially in frail MM patients with AL amyloidosis, indicating the importance of retaining physical functions to prevent SRE. John Wiley and Sons Inc. 2022-02-28 /pmc/articles/PMC9175803/ /pubmed/35846024 http://dx.doi.org/10.1002/jha2.402 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Miki, Hirokazu
Nakamura, Shingen
Oura, Masahiro
Nakamura, Masafumi
Sumitani, Ryohei
Sogabe, Kimiko
Takahashi, Mamiko
Maruhashi, Tomoko
Harada, Takeshi
Fujii, Shiro
Hamano, Hirofumi
Kondo, Masateru
Okada, Naoto
Endo, Itsuro
Abe, Masahiro
The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
title The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
title_full The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
title_fullStr The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
title_full_unstemmed The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
title_short The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
title_sort importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175803/
https://www.ncbi.nlm.nih.gov/pubmed/35846024
http://dx.doi.org/10.1002/jha2.402
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