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Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis

Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used in select cases with heparin‐induced thrombocytopenia (HIT). In a cross‐sectional analysis, a propensity matched sample was generated by IVIG or TPE treatment status to assess the primary outcome of mortality. In 500 HI...

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Autores principales: Soares Ferreira Júnior, Alexandre, Boyle, Stephen H., Kuchibhatla, Maragatha, Onwuemene, Oluwatoyosi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175867/
https://www.ncbi.nlm.nih.gov/pubmed/35844687
http://dx.doi.org/10.1002/jha2.211
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author Soares Ferreira Júnior, Alexandre
Boyle, Stephen H.
Kuchibhatla, Maragatha
Onwuemene, Oluwatoyosi A.
author_facet Soares Ferreira Júnior, Alexandre
Boyle, Stephen H.
Kuchibhatla, Maragatha
Onwuemene, Oluwatoyosi A.
author_sort Soares Ferreira Júnior, Alexandre
collection PubMed
description Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used in select cases with heparin‐induced thrombocytopenia (HIT). In a cross‐sectional analysis, a propensity matched sample was generated by IVIG or TPE treatment status to assess the primary outcome of mortality. In 500 HIT cases, IVIG or TPE was not associated with increased mortality (OR = 1.46; 95% CI: 0.81–2.63, p = 0.2052) but was associated with a higher likelihood of major bleeding (OR = 1.75; 95% CI: 1.03–2.96, p = 0.0376). The use of IVIG or TPE in HIT cases with bleeding contraindications to standard therapies should be further investigated.
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spelling pubmed-91758672022-07-14 Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis Soares Ferreira Júnior, Alexandre Boyle, Stephen H. Kuchibhatla, Maragatha Onwuemene, Oluwatoyosi A. EJHaem Short Reports Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used in select cases with heparin‐induced thrombocytopenia (HIT). In a cross‐sectional analysis, a propensity matched sample was generated by IVIG or TPE treatment status to assess the primary outcome of mortality. In 500 HIT cases, IVIG or TPE was not associated with increased mortality (OR = 1.46; 95% CI: 0.81–2.63, p = 0.2052) but was associated with a higher likelihood of major bleeding (OR = 1.75; 95% CI: 1.03–2.96, p = 0.0376). The use of IVIG or TPE in HIT cases with bleeding contraindications to standard therapies should be further investigated. John Wiley and Sons Inc. 2021-05-07 /pmc/articles/PMC9175867/ /pubmed/35844687 http://dx.doi.org/10.1002/jha2.211 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Soares Ferreira Júnior, Alexandre
Boyle, Stephen H.
Kuchibhatla, Maragatha
Onwuemene, Oluwatoyosi A.
Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
title Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
title_full Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
title_fullStr Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
title_full_unstemmed Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
title_short Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
title_sort bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: a propensity matched analysis
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175867/
https://www.ncbi.nlm.nih.gov/pubmed/35844687
http://dx.doi.org/10.1002/jha2.211
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