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Primary central nervous system lymphoma: Inter‐compartmental progression

There is limited understanding of the inter‐compartmental progression and treatment outcomes of primary central nervous system lymphoma (PCNSL). In this multicenter retrospective cohort study on 234 patients with PCNSL (median age: 62.5 years [18–92]; median follow‐up 35 months [0.1–237.0]) from 200...

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Autores principales: Raval, Vishal, Binkley, Elaine, Aronow, Mary E., Valenzuela, Juan, Peereboom, David M., Wei, Wei, Srivastava, Sunil, Davanzo, Jaqueline, Boldt, Herbert Culver, McGarrey, Mark P., Papaliodis, George N., Sobrin, Lucia, Kim, Ivana K., Vavvas, Dimitrios G., Eliott, Dean, Nayak, Lakshmi, Dodds, Emilio, Marco del Pont, Francisco, Singh, Arun D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175875/
https://www.ncbi.nlm.nih.gov/pubmed/35846050
http://dx.doi.org/10.1002/jha2.303
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author Raval, Vishal
Binkley, Elaine
Aronow, Mary E.
Valenzuela, Juan
Peereboom, David M.
Wei, Wei
Srivastava, Sunil
Davanzo, Jaqueline
Boldt, Herbert Culver
McGarrey, Mark P.
Papaliodis, George N.
Sobrin, Lucia
Kim, Ivana K.
Vavvas, Dimitrios G.
Eliott, Dean
Nayak, Lakshmi
Dodds, Emilio
Marco del Pont, Francisco
Singh, Arun D.
author_facet Raval, Vishal
Binkley, Elaine
Aronow, Mary E.
Valenzuela, Juan
Peereboom, David M.
Wei, Wei
Srivastava, Sunil
Davanzo, Jaqueline
Boldt, Herbert Culver
McGarrey, Mark P.
Papaliodis, George N.
Sobrin, Lucia
Kim, Ivana K.
Vavvas, Dimitrios G.
Eliott, Dean
Nayak, Lakshmi
Dodds, Emilio
Marco del Pont, Francisco
Singh, Arun D.
author_sort Raval, Vishal
collection PubMed
description There is limited understanding of the inter‐compartmental progression and treatment outcomes of primary central nervous system lymphoma (PCNSL). In this multicenter retrospective cohort study on 234 patients with PCNSL (median age: 62.5 years [18–92]; median follow‐up 35 months [0.1–237.0]) from 2000 till 2018 were divided into group 1 (ocular, 44 patients): 1A and 1B without and with CNS progression and group 2 (CNS, 190 patients): 2A and 2B without and with ocular progression, respectively. In group 1 (44 patients), 33 patients received local treatment, and 11 patients received systemic treatment. In group 2 (15 patients), six patients received combination treatment, while seven patients received only systemic treatment. A complete response was observed in 19 (43%) and 91 (48%) patients in groups 1 and 2, respectively. The 2‐year progression‐free survival (PFS) was 35% (95% CI: 0.23, 0.54) and 56% (95% CI: 0.49, 0.63) for groups 1 and 2, respectively (p < 0.0001). Age < 60 years was significantly associated with longer PFS (median PFS 48 vs. 24 months, p = 0.01). The overall survival (OS) at 2‐year was similar among groups 1 and 2 (83% and 67%), respectively (p = 0.06). Thus, Initial compartment of involvement does not influence local response rate or OS.
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spelling pubmed-91758752022-07-14 Primary central nervous system lymphoma: Inter‐compartmental progression Raval, Vishal Binkley, Elaine Aronow, Mary E. Valenzuela, Juan Peereboom, David M. Wei, Wei Srivastava, Sunil Davanzo, Jaqueline Boldt, Herbert Culver McGarrey, Mark P. Papaliodis, George N. Sobrin, Lucia Kim, Ivana K. Vavvas, Dimitrios G. Eliott, Dean Nayak, Lakshmi Dodds, Emilio Marco del Pont, Francisco Singh, Arun D. EJHaem Haematologic Malignancy ‐ Lymphoid There is limited understanding of the inter‐compartmental progression and treatment outcomes of primary central nervous system lymphoma (PCNSL). In this multicenter retrospective cohort study on 234 patients with PCNSL (median age: 62.5 years [18–92]; median follow‐up 35 months [0.1–237.0]) from 2000 till 2018 were divided into group 1 (ocular, 44 patients): 1A and 1B without and with CNS progression and group 2 (CNS, 190 patients): 2A and 2B without and with ocular progression, respectively. In group 1 (44 patients), 33 patients received local treatment, and 11 patients received systemic treatment. In group 2 (15 patients), six patients received combination treatment, while seven patients received only systemic treatment. A complete response was observed in 19 (43%) and 91 (48%) patients in groups 1 and 2, respectively. The 2‐year progression‐free survival (PFS) was 35% (95% CI: 0.23, 0.54) and 56% (95% CI: 0.49, 0.63) for groups 1 and 2, respectively (p < 0.0001). Age < 60 years was significantly associated with longer PFS (median PFS 48 vs. 24 months, p = 0.01). The overall survival (OS) at 2‐year was similar among groups 1 and 2 (83% and 67%), respectively (p = 0.06). Thus, Initial compartment of involvement does not influence local response rate or OS. John Wiley and Sons Inc. 2022-01-20 /pmc/articles/PMC9175875/ /pubmed/35846050 http://dx.doi.org/10.1002/jha2.303 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Haematologic Malignancy ‐ Lymphoid
Raval, Vishal
Binkley, Elaine
Aronow, Mary E.
Valenzuela, Juan
Peereboom, David M.
Wei, Wei
Srivastava, Sunil
Davanzo, Jaqueline
Boldt, Herbert Culver
McGarrey, Mark P.
Papaliodis, George N.
Sobrin, Lucia
Kim, Ivana K.
Vavvas, Dimitrios G.
Eliott, Dean
Nayak, Lakshmi
Dodds, Emilio
Marco del Pont, Francisco
Singh, Arun D.
Primary central nervous system lymphoma: Inter‐compartmental progression
title Primary central nervous system lymphoma: Inter‐compartmental progression
title_full Primary central nervous system lymphoma: Inter‐compartmental progression
title_fullStr Primary central nervous system lymphoma: Inter‐compartmental progression
title_full_unstemmed Primary central nervous system lymphoma: Inter‐compartmental progression
title_short Primary central nervous system lymphoma: Inter‐compartmental progression
title_sort primary central nervous system lymphoma: inter‐compartmental progression
topic Haematologic Malignancy ‐ Lymphoid
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175875/
https://www.ncbi.nlm.nih.gov/pubmed/35846050
http://dx.doi.org/10.1002/jha2.303
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