Artemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo

Loss of endoplasmic reticulum (ER) homeostasis leads to ER stress, thus prolonged activation can lead to apoptosis. Herein, artesunate (ART) induced ER stress in leukaemia cells, resulting in eIF2α phosphorylation, activation of transcription factor 4, subsequent CHOP upregulation and XBP1 splicing....

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Detalles Bibliográficos
Autores principales: Mancuso, Rubia Isler, Azambuja, Juliana Hofstätter, Niemann, Fernanda Soares, Congrains, Ada, Foglio, Mary Ann, Rego, Eduardo Magalhães, Olalla Saad, Sara Teresinha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175883/
https://www.ncbi.nlm.nih.gov/pubmed/35845184
http://dx.doi.org/10.1002/jha2.314

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