Cargando…

Mechanism of increased efficacy of recombinant Fc‐μTP‐L309C compared to IVIg to ameliorate mouse immune thrombocytopenia

Recombinant Fc‐μTP‐L309C is more efficacious than intravenous immunoglobulin (IVIg) at ameliorating antibody‐mediated autoimmune diseases through its effects on Fcγ receptors (FcγRs). Fc‐μTP‐L309C inhibited in‐vitro FcγR‐mediated phagocytosis 10(4)/10(5)‐fold better than IVIg. Fc‐μTP‐L309C, given su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lewis, Bonnie J.B., Binnington, Beth, Blacquiere, Megan, Spirig, Rolf, Käsermann, Fabian, Branch, Donald R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Short Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175896/ https://www.ncbi.nlm.nih.gov/pubmed/35845218 http://dx.doi.org/10.1002/jha2.304

Ejemplares similares

Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer
por: Lewis, Bonnie J. B., et al.
Publicado: (2019)

Modulation of Neutrophil Function by Recombinant Human IgG1 Fc Hexamer in the Endogenous K/BxN Mouse Model of Rheumatoid Arthritis
por: Almizraq, Ruqayyah J., et al.
Publicado: (2023)

IVIG regulates the survival of human but not mouse neutrophils
por: Schneider, Christoph, et al.
Publicado: (2017)

IVIg attenuates complement and improves spinal cord injury outcomes in mice
por: Brennan, Faith H., et al.
Publicado: (2016)

Analysis and Functional Consequences of Increased Fab-Sialylation of Intravenous Immunoglobulin (IVIG) after Lectin Fractionation
por: Käsermann, Fabian, et al.
Publicado: (2012)

Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications
por: Czajkowsky, Daniel M., et al.
Publicado: (2015)

Prednisone plus IVIg compared with prednisone or IVIg for immune thrombocytopenia in pregnancy: a national retrospective cohort study
por: Zhu, Xiao-Lu, et al.
Publicado: (2022)

An antivenin resistant, IVIg-corticosteroids responsive viper induced thrombocytopenia
por: Turetta, Matteo, et al.
Publicado: (2022)

IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia
por: Herrmann, Alyssa, et al.
Publicado: (2017)

Role of Anticoagulation and IVIG in Treatment of Vaccine-Induced Thrombotic Thrombocytopenia (VITT)
por: Tariq, Anosha, et al.
Publicado: (2022)

Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?
por: Nagelkerke, Sietse Q., et al.
Publicado: (2015)

Amelioration of Murine Passive Immune Thrombocytopenia by IVIg and a Therapeutic Monoclonal CD44 Antibody Does Not Require the Myd88 Signaling Pathway
por: Crow, Andrew R., et al.
Publicado: (2013)

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
por: Hori, Yasuki, et al.
Publicado: (2015)

Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer
por: YONEDA, TOMOKO, et al.
Publicado: (2013)

Correction: Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
Publicado: (2015)

Intravenous Immunoglobulin (IVIg) Utilization in Immune Thrombocytopenia (ITP): A Multi-Center, Retrospective Review
por: Hsia, Cyrus C., et al.
Publicado: (2015)

Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS
por: Fokkink, Willem‐Jan R., et al.
Publicado: (2016)

The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors
por: Dalakas, Marinos C., et al.
Publicado: (2021)

Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome
por: Chan, Ying, et al.
Publicado: (2016)

Treatment of scleromyxedema with IVIg
por: Moser, David W, et al.
Publicado: (2012)

Health Tract No. 309: Comfort
Publicado: (1868)

Methylprednisolone Pulse Therapy or Additional IVIG for Patients with IVIG-Resistant Kawasaki Disease
por: Wang, Zhouping, et al.
Publicado: (2020)

Identity of the elusive IgM Fc receptor (FcμR) in humans
por: Kubagawa, Hiromi, et al.
Publicado: (2009)

Mapping of the binding site for FcμR in human IgM-Fc
por: Nyamboya, Rosemary A., et al.
Publicado: (2020)

FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia
por: Norris, Peter A. A., et al.
Publicado: (2020)

A Comparative Study of IVIG versus IVIG with IV Methylprednisolone in Guillain–Barre Syndrome
por: Bhattiprolu, Rahi Kiran, et al.
Publicado: (2020)

Treatment of refractory delayed onset heparin‐induced thrombocytopenia after thoracic endovascular aortic repair with intravenous immunoglobulin (IVIG)
por: Doucette, Kimberley, et al.
Publicado: (2017)

Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)
por: Straubel, Diana, et al.
Publicado: (2018)

Cooling down VITT with IVIG
por: Lentz, Steven R.
Publicado: (2021)

Intravenous Immunoglobulin Gamma (IVIG) versus IVIG Plus Infliximab in Young Children with Kawasaki Disease
por: Han, Chun-Ling, et al.
Publicado: (2018)

FcγRIIa and FcγRIIIa genes polymorphism in Egyptian children with primary immune thrombocytopenia
por: Zakaria, Marwa, et al.
Publicado: (2023)

Study on the Treatment of ITP Mice with IVIG Sourced from Distinct Sex-Special Plasma (DSP-IVIG)
por: Zhang, Wei, et al.
Publicado: (2023)

Isolation and Characterization of Lytic Proteus Virus 309
por: Aaron, Joshua, et al.
Publicado: (2022)

IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice
por: Akyol, Gokce Yilmaz, et al.
Publicado: (2017)

Eczematous reaction to IVIG for the treatment of dermatomyositis()()
por: Berk-Krauss, J., et al.
Publicado: (2018)

Refractory Heparin-Induced Thrombocytopenia With Cerebral Venous Sinus Thrombosis Treated With IVIg, Steroids, and a Combination of Anticoagulants: A Case Report
por: Gonzales, Mia, et al.
Publicado: (2019)

Therapeutic Window of Intravenous Immunoglobulin (IVIG) and its correlation with IVIG-resistant in Kawasaki Disease: a retrospective study
por: Cai, Jiang Hui, et al.
Publicado: (2022)

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Sinilnikova, O M, et al.
Publicado: (2009)

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study
por: Ebrahim Abadi, Zeinab, et al.
Publicado: (2018)

Reply to: Questioning whether the IgM Fc receptor (FcμR) is expressed by innate immune cells
por: Kubli, Shawn P., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kfjo3me0q3v4fku7385pj3v1u9