A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom

Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body...

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Autores principales: Flinn, Aisling M., Macheka, Sheba, Slatter, Mary, Ewins, Anna‐Maria, Gibson, Brenda, Lawson, Sarah, Tailby, Anna, Lucchini, Giovanna, New, Helen, James, Beki, Alfred, Arun, Scarisbrick, Julia, Gennery, Andrew R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175897/
https://www.ncbi.nlm.nih.gov/pubmed/35847736
http://dx.doi.org/10.1002/jha2.58
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author Flinn, Aisling M.
Macheka, Sheba
Slatter, Mary
Ewins, Anna‐Maria
Gibson, Brenda
Lawson, Sarah
Tailby, Anna
Lucchini, Giovanna
New, Helen
James, Beki
Alfred, Arun
Scarisbrick, Julia
Gennery, Andrew R
author_facet Flinn, Aisling M.
Macheka, Sheba
Slatter, Mary
Ewins, Anna‐Maria
Gibson, Brenda
Lawson, Sarah
Tailby, Anna
Lucchini, Giovanna
New, Helen
James, Beki
Alfred, Arun
Scarisbrick, Julia
Gennery, Andrew R
author_sort Flinn, Aisling M.
collection PubMed
description Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body weight patients. Most patients were on multiple immunosuppressive therapies prior to ECP; 45.9% were able to reduce or stop immunosuppression with treatment. Complete or partial response was reported in almost 60%. This study supports the need to include ECP treatment data to national transplant databases to provide accurate information regarding service provision, patient outcomes, and safety.
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spelling pubmed-91758972022-07-14 A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom Flinn, Aisling M. Macheka, Sheba Slatter, Mary Ewins, Anna‐Maria Gibson, Brenda Lawson, Sarah Tailby, Anna Lucchini, Giovanna New, Helen James, Beki Alfred, Arun Scarisbrick, Julia Gennery, Andrew R EJHaem Short Reports Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body weight patients. Most patients were on multiple immunosuppressive therapies prior to ECP; 45.9% were able to reduce or stop immunosuppression with treatment. Complete or partial response was reported in almost 60%. This study supports the need to include ECP treatment data to national transplant databases to provide accurate information regarding service provision, patient outcomes, and safety. John Wiley and Sons Inc. 2020-07-13 /pmc/articles/PMC9175897/ /pubmed/35847736 http://dx.doi.org/10.1002/jha2.58 Text en © 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Flinn, Aisling M.
Macheka, Sheba
Slatter, Mary
Ewins, Anna‐Maria
Gibson, Brenda
Lawson, Sarah
Tailby, Anna
Lucchini, Giovanna
New, Helen
James, Beki
Alfred, Arun
Scarisbrick, Julia
Gennery, Andrew R
A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
title A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
title_full A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
title_fullStr A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
title_full_unstemmed A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
title_short A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
title_sort survey of extracorporeal photopheresis treatment in pediatric patients in the united kingdom
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175897/
https://www.ncbi.nlm.nih.gov/pubmed/35847736
http://dx.doi.org/10.1002/jha2.58
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