Adult T cell leukaemia/lymphoma (ATL) in pregnancy: A UK case series

INTRODUCTION: Chronic infection with human T‐cell lymphotropic virus type‐1 (HTLV‐1) may result in aggressive adult T‐cell leukaemia/lymphoma (ATL) in 4‐6% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has ∼25% lifetime risk. Other risk factors in...

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Detalles Bibliográficos
Autores principales: Motedayen Aval, Leila, Boullier, Mary, Lyall, Hermione, Collins, Graham P., Ayto, Robert, Kelly, Dominic F., Tedder, Richard S., Drysdale, Simon B., Taylor, Graham P., Cook, Lucy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175930/
https://www.ncbi.nlm.nih.gov/pubmed/35846087
http://dx.doi.org/10.1002/jha2.142
Descripción
Sumario:INTRODUCTION: Chronic infection with human T‐cell lymphotropic virus type‐1 (HTLV‐1) may result in aggressive adult T‐cell leukaemia/lymphoma (ATL) in 4‐6% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has ∼25% lifetime risk. Other risk factors include a family history of ATL. Antenatal HTLV‐1 screening is not undertaken in the UK. METHODS: Here we describe four cases of ATL diagnosed during pregnancy and describe strategies to minimise HTLV‐1 transmission to neonates. RESULTS/CONCLUSION: These cases highlight undiagnosed HTLV‐1 in pregnancy which allows ongoing mother to child vertical transmission and risk of future ATL. We recommend the UK National Screening Committee incorporate HTLV‐1 serology into antenatal screening.

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