Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026. The mechanism underlying increased bleeding tendency with Btk inhibitors remains unclear...

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Detalles Bibliográficos
Autores principales: Tullemans, Bibian M.E., Karel, Mieke F.A., Léopold, Valentine, ten Brink, Marieke S., Baaten, Constance C.F.M.J., Maas, Sanne L., de Vos, Alex F., Eble, Johannes A., Nijziel, Marten R., van der Vorst, Emiel P.C., Cosemans, Judith M.E.M., Heemskerk, Johan W.M., Claushuis, Theodora A.M., Kuijpers, Marijke J.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Sickle Cell, Thrombosis, and Benign Haematology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175945/
https://www.ncbi.nlm.nih.gov/pubmed/35845214
http://dx.doi.org/10.1002/jha2.269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175945/
https://www.ncbi.nlm.nih.gov/pubmed/35845214
http://dx.doi.org/10.1002/jha2.269

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