Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation

Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv...

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Detalles Bibliográficos
Autores principales: Avenoso, Daniele, Krishnamurthy, Pramila, Salisbury, Jonathan, Rashid, Sabia, Gandhi, Shreyans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Haematology Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175950/
https://www.ncbi.nlm.nih.gov/pubmed/35845194
http://dx.doi.org/10.1002/jha2.289
Descripción
Sumario:Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts.

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