Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation

Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv...

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Autores principales: Avenoso, Daniele, Krishnamurthy, Pramila, Salisbury, Jonathan, Rashid, Sabia, Gandhi, Shreyans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Haematology Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175950/
https://www.ncbi.nlm.nih.gov/pubmed/35845194
http://dx.doi.org/10.1002/jha2.289
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author Avenoso, Daniele
Krishnamurthy, Pramila
Salisbury, Jonathan
Rashid, Sabia
Gandhi, Shreyans
author_facet Avenoso, Daniele
Krishnamurthy, Pramila
Salisbury, Jonathan
Rashid, Sabia
Gandhi, Shreyans
author_sort Avenoso, Daniele
collection PubMed
description Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts.
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spelling pubmed-91759502022-07-14 Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation Avenoso, Daniele Krishnamurthy, Pramila Salisbury, Jonathan Rashid, Sabia Gandhi, Shreyans EJHaem Haematology Images Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts. John Wiley and Sons Inc. 2021-10-01 /pmc/articles/PMC9175950/ /pubmed/35845194 http://dx.doi.org/10.1002/jha2.289 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Haematology Images
Avenoso, Daniele
Krishnamurthy, Pramila
Salisbury, Jonathan
Rashid, Sabia
Gandhi, Shreyans
Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
title Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
title_full Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
title_fullStr Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
title_full_unstemmed Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
title_short Unusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
title_sort unusual cd34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
topic Haematology Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175950/
https://www.ncbi.nlm.nih.gov/pubmed/35845194
http://dx.doi.org/10.1002/jha2.289
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