High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis

We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly highe...

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Autores principales: Kohli, Shruti, Chadha, Ritu, Rastogi, Neha, Yadav, Satya Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175966/
https://www.ncbi.nlm.nih.gov/pubmed/35846094
http://dx.doi.org/10.1002/jha2.153
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author Kohli, Shruti
Chadha, Ritu
Rastogi, Neha
Yadav, Satya Prakash
author_facet Kohli, Shruti
Chadha, Ritu
Rastogi, Neha
Yadav, Satya Prakash
author_sort Kohli, Shruti
collection PubMed
description We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly higher (P‐value .0048) in patients with serum ferritin levels >5000 ug/dL. Of 21 patients with high serum ferritin, a median of three criteria were fulfilled to diagnose HLH. All patients had features of immune‐activation, and 76.2% patients had features of immune‐pathology favoring diagnosis of HLH. Serum ferritin can aid in prediction of mortality and help in the early diagnosis of HLH.
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spelling pubmed-91759662022-07-14 High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis Kohli, Shruti Chadha, Ritu Rastogi, Neha Yadav, Satya Prakash EJHaem Case Reports We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly higher (P‐value .0048) in patients with serum ferritin levels >5000 ug/dL. Of 21 patients with high serum ferritin, a median of three criteria were fulfilled to diagnose HLH. All patients had features of immune‐activation, and 76.2% patients had features of immune‐pathology favoring diagnosis of HLH. Serum ferritin can aid in prediction of mortality and help in the early diagnosis of HLH. John Wiley and Sons Inc. 2021-01-06 /pmc/articles/PMC9175966/ /pubmed/35846094 http://dx.doi.org/10.1002/jha2.153 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Kohli, Shruti
Chadha, Ritu
Rastogi, Neha
Yadav, Satya Prakash
High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
title High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
title_full High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
title_fullStr High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
title_full_unstemmed High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
title_short High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
title_sort high serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175966/
https://www.ncbi.nlm.nih.gov/pubmed/35846094
http://dx.doi.org/10.1002/jha2.153
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