Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1

A 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK‐NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone mar...

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Detalles Bibliográficos
Autores principales: Hagiwara, Shinya, Kusumoto, Shigeru, Ito, Asahi, Masaki, Ayako, Shiraga, Kazuhide, Tachita, Takuto, Hirade, Kentaro, Oiwa, Kana, Suzuki, Tomotaka, Kinoshita, Shiori, Ri, Masaki, Ito, Yasuhiko, Komatsu, Hirokazu, Inagaki, Hiroshi, Iida, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175994/
https://www.ncbi.nlm.nih.gov/pubmed/35845276
http://dx.doi.org/10.1002/jha2.169
Descripción
Sumario:A 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK‐NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone marrow aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), a chimeric RUNX1‐RUNX1T1 (not DEK‐NUP214) fusion gene, was detected with full donor chimerism. To our best knowledge, this is the first case of a volunteer unrelated donor cell‐derived acute myeloid leukemia harboring a chimeric RUNX1‐RUNX1T1 fusion gene.

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