Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults

We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on...

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Detalles Bibliográficos
Autores principales: Konuma, Takaaki, Monna‐Oiwa, Maki, Takano, Kosuke, Isobe, Masamichi, Kato, Seiko, Takahashi, Satoshi, Nannya, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176115/
https://www.ncbi.nlm.nih.gov/pubmed/35846188
http://dx.doi.org/10.1002/jha2.372
Descripción
Sumario:We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation.

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