Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults

We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on...

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Autores principales: Konuma, Takaaki, Monna‐Oiwa, Maki, Takano, Kosuke, Isobe, Masamichi, Kato, Seiko, Takahashi, Satoshi, Nannya, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176115/
https://www.ncbi.nlm.nih.gov/pubmed/35846188
http://dx.doi.org/10.1002/jha2.372
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author Konuma, Takaaki
Monna‐Oiwa, Maki
Takano, Kosuke
Isobe, Masamichi
Kato, Seiko
Takahashi, Satoshi
Nannya, Yasuhito
author_facet Konuma, Takaaki
Monna‐Oiwa, Maki
Takano, Kosuke
Isobe, Masamichi
Kato, Seiko
Takahashi, Satoshi
Nannya, Yasuhito
author_sort Konuma, Takaaki
collection PubMed
description We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation.
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spelling pubmed-91761152022-07-14 Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults Konuma, Takaaki Monna‐Oiwa, Maki Takano, Kosuke Isobe, Masamichi Kato, Seiko Takahashi, Satoshi Nannya, Yasuhito EJHaem Short Reports We retrospectively evaluated the optimal time and threshold of absolute lymphocyte count (ALC) recovery as a prognostic factor in 174 adult patients who received single‐unit cord blood transplantation (CBT) at our institute. We analyzed the impact of ALC ≥300, ≥600, and ≥900/μl by 30 and 60 days on transplant outcomes. Multivariate analysis showed that only ALC ≥300/μl at 60 days was significantly associated with overall mortality (hazard ratio, 0.24; p = 0.001) following CBT. The optimal time point to use ALC recovery as a prognostic tool following CBT could be later than those following adult donor transplantation. John Wiley and Sons Inc. 2021-12-29 /pmc/articles/PMC9176115/ /pubmed/35846188 http://dx.doi.org/10.1002/jha2.372 Text en © 2021 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Konuma, Takaaki
Monna‐Oiwa, Maki
Takano, Kosuke
Isobe, Masamichi
Kato, Seiko
Takahashi, Satoshi
Nannya, Yasuhito
Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
title Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
title_full Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
title_fullStr Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
title_full_unstemmed Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
title_short Optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
title_sort optimal time and threshold of absolute lymphocyte count recovery as a prognostic factor after single‐unit cord blood transplantation in adults
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176115/
https://www.ncbi.nlm.nih.gov/pubmed/35846188
http://dx.doi.org/10.1002/jha2.372
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