Haematological malignancies in relatives of patients affected with myeloproliferative neoplasms

In a cohort of 3131 patients with myeloproliferative neoplasms (MPNs), we identified 200 patients (6.4%) who reported a second case of haematological malignancies (HM) in first‐ or second‐degree relatives. The occurrence of a second HM in the family was not influenced by MPN subtype, sex or driver m...

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Detalles Bibliográficos
Autores principales: Vanni, Daniele, Borsani, Oscar, Nannya, Yasuhito, Sant'Antonio, Emanuela, Trotti, Chiara, Casetti, Ilaria Carola, Pietra, Daniela, Gallì, Anna, Zibellini, Silvia, Ferretti, Virginia Valeria, Malcovati, Luca, Ogawa, Seishi, Arcaini, Luca, Rumi, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176120/
https://www.ncbi.nlm.nih.gov/pubmed/35846061
http://dx.doi.org/10.1002/jha2.425
Descripción
Sumario:In a cohort of 3131 patients with myeloproliferative neoplasms (MPNs), we identified 200 patients (6.4%) who reported a second case of haematological malignancies (HM) in first‐ or second‐degree relatives. The occurrence of a second HM in the family was not influenced by MPN subtype, sex or driver mutation, while it was associated with age at MPN diagnosis: 8.5% of patients diagnosed with MPN younger than 45 years had a second relative affected with HM compared to 5.5% of those diagnosed at the age of 45 years or older (p = 0.003), thus suggesting a genetic predisposition to HM with early onset.

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