BPDCN: When polychemotherapy does not compromise allogeneic CD123 CAR‐T cell cytotoxicity

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with poor prognosis and no treatment consensus. Combining chemotherapy and immunotherapy is a promising strategy to enhance therapeutic effect. Before combining these therapies, the influence of one on the other...

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Detalles Bibliográficos
Autores principales: Poussard, Margaux, Philippe, Laure, Fredon, Maxime, Bôle‐Richard, Elodie, Biichle, Sabeha, Renosi, Florian, Perrin, Sophie, Kroemer, Marie, Limat, Samuel, Bonnefoy, Francis, Daguindau, Etienne, Deconinck, Eric, Gruson, Bérengère, Saas, Philippe, Adotévi, Olivier, Garnache‐Ottou, Francine, Angelot‐Delettre, Fanny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176134/
https://www.ncbi.nlm.nih.gov/pubmed/35846081
http://dx.doi.org/10.1002/jha2.149
Descripción
Sumario:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with poor prognosis and no treatment consensus. Combining chemotherapy and immunotherapy is a promising strategy to enhance therapeutic effect. Before combining these therapies, the influence of one on the other has to be explored. We set up a model to test the combination of polychemotherapy ‐ named methotrexate, idarubicine, dexamethasone, and L‐asparaginase (MIDA) ‐ and CD123 CAR‐T cell therapy. We showed that CD123 CAR‐T cells exert the same effect on BPDCN models alone, or after MIDA regimen. These data support a preclinical rationale to use immunotherapy after a treatment with polychemotherapy for BPDCN patients.

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