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Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry

Health‐related quality of life (HRQoL) in patients with chronic lymphocytic leukemia (CLL) is important in guiding treatment decisions. However, the impact of CLL treatment initiation on HRQoL is unclear. We assessed HRQoL using the FACT‐Leu and EQ‐5D‐3L questionnaires in the Connect (®) CLL Registr...

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Autores principales: Sharman, Jeff P., Cocks, Kim, Nabhan, Chadi, Lamanna, Nicole, Kay, Neil E., Grinblatt, David L., Flowers, Christopher R., Davids, Matthew S., Kiselev, Pavel, Swern, Arlene S., Sullivan, Kristen, Gharibo, Mecide M., Flick, E. Dawn, Trigg, Andrew, Mato, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176138/
https://www.ncbi.nlm.nih.gov/pubmed/35847738
http://dx.doi.org/10.1002/jha2.67
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author Sharman, Jeff P.
Cocks, Kim
Nabhan, Chadi
Lamanna, Nicole
Kay, Neil E.
Grinblatt, David L.
Flowers, Christopher R.
Davids, Matthew S.
Kiselev, Pavel
Swern, Arlene S.
Sullivan, Kristen
Gharibo, Mecide M.
Flick, E. Dawn
Trigg, Andrew
Mato, Anthony
author_facet Sharman, Jeff P.
Cocks, Kim
Nabhan, Chadi
Lamanna, Nicole
Kay, Neil E.
Grinblatt, David L.
Flowers, Christopher R.
Davids, Matthew S.
Kiselev, Pavel
Swern, Arlene S.
Sullivan, Kristen
Gharibo, Mecide M.
Flick, E. Dawn
Trigg, Andrew
Mato, Anthony
author_sort Sharman, Jeff P.
collection PubMed
description Health‐related quality of life (HRQoL) in patients with chronic lymphocytic leukemia (CLL) is important in guiding treatment decisions. However, the impact of CLL treatment initiation on HRQoL is unclear. We assessed HRQoL using the FACT‐Leu and EQ‐5D‐3L questionnaires in the Connect (®) CLL Registry, a large, US‐based, multicenter, prospective observational study of CLL patients enrolled between 2010 and 2014, prior to the introduction of novel therapies. Among 889 patients initiating first‐line therapy with chemoimmunotherapy or rituximab monotherapy, questionnaire completion rates were 95.7% and 95.8% at enrollment, and 70.8% and 69.4% at 12 months, for FACT‐Leu Total and EQ‐5D‐3L, respectively. For 849 patients completing all five FACT‐Leu components, average total scores were 135.7 at enrollment and 141.6 at 12 months. Among 526 patients with FACT‐Leu Total scores at enrollment and 12 months, clinically meaningful (≥11‐point) improvements or reductions were observed in 179 (34.0%) and 88 (16.7%) patients, respectively. Mean EQ‐5D‐3L index scores were 0.87 at enrollment and 12 months. Among 513 patients completing EQ‐5D‐3L at enrollment and 12 months, clinically meaningful (≥0.06‐point) improvements or reductions were observed in 125 (24.4%) and 116 (22.6%) patients, respectively. In the Connect(®) CLL Registry, HRQoL remained stable or slightly improved after 12 months of follow‐up.
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spelling pubmed-91761382022-07-14 Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry Sharman, Jeff P. Cocks, Kim Nabhan, Chadi Lamanna, Nicole Kay, Neil E. Grinblatt, David L. Flowers, Christopher R. Davids, Matthew S. Kiselev, Pavel Swern, Arlene S. Sullivan, Kristen Gharibo, Mecide M. Flick, E. Dawn Trigg, Andrew Mato, Anthony EJHaem Haematologic Malignancy ‐ Lymphoid Health‐related quality of life (HRQoL) in patients with chronic lymphocytic leukemia (CLL) is important in guiding treatment decisions. However, the impact of CLL treatment initiation on HRQoL is unclear. We assessed HRQoL using the FACT‐Leu and EQ‐5D‐3L questionnaires in the Connect (®) CLL Registry, a large, US‐based, multicenter, prospective observational study of CLL patients enrolled between 2010 and 2014, prior to the introduction of novel therapies. Among 889 patients initiating first‐line therapy with chemoimmunotherapy or rituximab monotherapy, questionnaire completion rates were 95.7% and 95.8% at enrollment, and 70.8% and 69.4% at 12 months, for FACT‐Leu Total and EQ‐5D‐3L, respectively. For 849 patients completing all five FACT‐Leu components, average total scores were 135.7 at enrollment and 141.6 at 12 months. Among 526 patients with FACT‐Leu Total scores at enrollment and 12 months, clinically meaningful (≥11‐point) improvements or reductions were observed in 179 (34.0%) and 88 (16.7%) patients, respectively. Mean EQ‐5D‐3L index scores were 0.87 at enrollment and 12 months. Among 513 patients completing EQ‐5D‐3L at enrollment and 12 months, clinically meaningful (≥0.06‐point) improvements or reductions were observed in 125 (24.4%) and 116 (22.6%) patients, respectively. In the Connect(®) CLL Registry, HRQoL remained stable or slightly improved after 12 months of follow‐up. John Wiley and Sons Inc. 2020-07-26 /pmc/articles/PMC9176138/ /pubmed/35847738 http://dx.doi.org/10.1002/jha2.67 Text en © 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Haematologic Malignancy ‐ Lymphoid
Sharman, Jeff P.
Cocks, Kim
Nabhan, Chadi
Lamanna, Nicole
Kay, Neil E.
Grinblatt, David L.
Flowers, Christopher R.
Davids, Matthew S.
Kiselev, Pavel
Swern, Arlene S.
Sullivan, Kristen
Gharibo, Mecide M.
Flick, E. Dawn
Trigg, Andrew
Mato, Anthony
Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry
title Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry
title_full Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry
title_fullStr Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry
title_full_unstemmed Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry
title_short Longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: Results from the Connect(®) CLL Registry
title_sort longitudinal health‐related quality of life in first‐line treated patients with chronic lymphocytic leukemia: results from the connect(®) cll registry
topic Haematologic Malignancy ‐ Lymphoid
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176138/
https://www.ncbi.nlm.nih.gov/pubmed/35847738
http://dx.doi.org/10.1002/jha2.67
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