A ROR1 small molecule inhibitor (KAN0441571C) induced significant apoptosis of ibrutinib‐resistant ROR1(+) CLL cells

ROR1 – a receptor tyrosine kinase – is overexpressed in CLL. Ibrutinib, a Bruton's tyrosine kinase inhibitor, is clinically effective in CLL but patients may develop resistance. We evaluated the effect of an ROR1 inhibitor, KAN0441571C, in CLL cells from six patients obtained before and after d...

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Detalles Bibliográficos
Autores principales: Ghaderi, Amineh, Okhovat, Mohammad‐Ali, Wikanthi, Layung Sekar Sih, Svensson, Ann, Palma, Marzia, Schultz, Johan, Olin, Thomas, Österborg, Anders, Mellstedt, Håkan, Hojjat‐Farsangi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176142/
https://www.ncbi.nlm.nih.gov/pubmed/35844694
http://dx.doi.org/10.1002/jha2.232

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