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Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach

[Image: see text] Lipid nanoparticles (LNPs) are the leading technology for RNA delivery, given the success of the Pfizer/BioNTech and Moderna COVID-19 mRNA (mRNA) vaccines, and small interfering RNA (siRNA) therapies (patisiran). However, optimization of LNP process parameters and compositions for...

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Detalles Bibliográficos
Autores principales:	Ly, Han Han, Daniel, Simon, Soriano, Shekinah K. V., Kis, Zoltán, Blakney, Anna K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176215/ https://www.ncbi.nlm.nih.gov/pubmed/35604765 http://dx.doi.org/10.1021/acs.molpharmaceut.2c00032

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