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Randomised trial of the P2X(3) receptor antagonist sivopixant for refractory chronic cough

BACKGROUND: The purinoceptor subtype P2X(3) has been shown to have significant involvement in the cough reflex; the heterotrimer version of the purinoceptor (P2X(2/3)) has been implicated in taste disturbance. The most advanced clinical candidate antagonist gefapixant has low selectivity among P2X(3...

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Detalles Bibliográficos
Autores principales:	Niimi, Akio, Saito, Junpei, Kamei, Tadashi, Shinkai, Masaharu, Ishihara, Hiroyuki, Machida, Mitsuaki, Miyazaki, Sayaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2022
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176336/ https://www.ncbi.nlm.nih.gov/pubmed/34649978 http://dx.doi.org/10.1183/13993003.00725-2021

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