mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron...

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Autores principales: Wang, Haomeng, Chen, Zhao, Wang, Zhenghua, Li, Jin, Yan, Zhihong, Yuan, Jinbo, Zhu, Airu, Chen, Lan, Liu, Ye, Hu, Chenlong, Zhu, Ali, Li, Guowei, Li, Yuehu, Deng, Jie, Ma, Liqiao, Sui, Xiuwen, Miao, Wei, Li, Junqiang, Zheng, Xiuyu, Piao, Jinhua, Yao, Yanfeng, Rao, Juhong, Shan, Chao, Yuan, Zhiming, Zhao, Jincun, Zhu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176361/
https://www.ncbi.nlm.nih.gov/pubmed/35604772
http://dx.doi.org/10.1080/22221751.2022.2081616
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author Wang, Haomeng
Chen, Zhao
Wang, Zhenghua
Li, Jin
Yan, Zhihong
Yuan, Jinbo
Zhu, Airu
Chen, Lan
Liu, Ye
Hu, Chenlong
Zhu, Ali
Li, Guowei
Li, Yuehu
Deng, Jie
Ma, Liqiao
Sui, Xiuwen
Miao, Wei
Li, Junqiang
Zheng, Xiuyu
Piao, Jinhua
Yao, Yanfeng
Rao, Juhong
Shan, Chao
Yuan, Zhiming
Zhao, Jincun
Zhu, Tao
author_facet Wang, Haomeng
Chen, Zhao
Wang, Zhenghua
Li, Jin
Yan, Zhihong
Yuan, Jinbo
Zhu, Airu
Chen, Lan
Liu, Ye
Hu, Chenlong
Zhu, Ali
Li, Guowei
Li, Yuehu
Deng, Jie
Ma, Liqiao
Sui, Xiuwen
Miao, Wei
Li, Junqiang
Zheng, Xiuyu
Piao, Jinhua
Yao, Yanfeng
Rao, Juhong
Shan, Chao
Yuan, Zhiming
Zhao, Jincun
Zhu, Tao
author_sort Wang, Haomeng
collection PubMed
description In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against different SARS-CoV-2 variants.
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spelling pubmed-91763612022-06-09 mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern Wang, Haomeng Chen, Zhao Wang, Zhenghua Li, Jin Yan, Zhihong Yuan, Jinbo Zhu, Airu Chen, Lan Liu, Ye Hu, Chenlong Zhu, Ali Li, Guowei Li, Yuehu Deng, Jie Ma, Liqiao Sui, Xiuwen Miao, Wei Li, Junqiang Zheng, Xiuyu Piao, Jinhua Yao, Yanfeng Rao, Juhong Shan, Chao Yuan, Zhiming Zhao, Jincun Zhu, Tao Emerg Microbes Infect Coronaviruses In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against different SARS-CoV-2 variants. Taylor & Francis 2022-06-04 /pmc/articles/PMC9176361/ /pubmed/35604772 http://dx.doi.org/10.1080/22221751.2022.2081616 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Coronaviruses
Wang, Haomeng
Chen, Zhao
Wang, Zhenghua
Li, Jin
Yan, Zhihong
Yuan, Jinbo
Zhu, Airu
Chen, Lan
Liu, Ye
Hu, Chenlong
Zhu, Ali
Li, Guowei
Li, Yuehu
Deng, Jie
Ma, Liqiao
Sui, Xiuwen
Miao, Wei
Li, Junqiang
Zheng, Xiuyu
Piao, Jinhua
Yao, Yanfeng
Rao, Juhong
Shan, Chao
Yuan, Zhiming
Zhao, Jincun
Zhu, Tao
mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern
title mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern
title_full mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern
title_fullStr mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern
title_full_unstemmed mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern
title_short mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern
title_sort mrna based vaccines provide broad protection against different sars-cov-2 variants of concern
topic Coronaviruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176361/
https://www.ncbi.nlm.nih.gov/pubmed/35604772
http://dx.doi.org/10.1080/22221751.2022.2081616
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