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How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla
CD4(+) T cell responses to self-antigens are pivotal for immunological self-tolerance. Activation of Foxp3(–) T-conventional (T-conv) cells can precipitate autoimmune disease, whereas activation of Foxp3(+) T-regulatory (T-reg) cells is essential to prevent autoimmune disease. This distinction indic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176388/ https://www.ncbi.nlm.nih.gov/pubmed/35693793 http://dx.doi.org/10.3389/fimmu.2022.892498 |