Design, synthesis and biological evaluation of novel diosgenin–benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells

To discover new lead compounds with anti-tumour activities, in the present study, natural diosgenin was hybridised with the reported benzoic acid mustard pharmacophore. The in vitro cytotoxicity of the resulting newly synthesised hybrids (8–10, 14a–14f, and 15a–15f) was then evaluated in three tumou...

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Detalles Bibliográficos
Autores principales: Zhang, Jinling, Wang, Wenbao, Tian, Yanzhao, Ma, Liwei, Zhou, Lin, Sun, Hao, Ma, Yukun, Hou, Huiling, Wang, Xiaoli, Ye, Jin, Wang, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176691/
https://www.ncbi.nlm.nih.gov/pubmed/35652316
http://dx.doi.org/10.1080/14756366.2022.2070161

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