Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage

BACKGROUND: The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant. METHODS: A...

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Detalles Bibliográficos
Autores principales: Kontogianni, Konstantina, Bengey, Daisy, Wooding, Dominic, Buist, Kate, Greenland-Bews, Caitlin, Williams, Christopher Thomas, de Vos, Margaretha, Santos, Victor Santana, Escadafal, Camille, Adams, Emily Rebecca, Edwards, Thomas, Cubas-Atienzar, Ana Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176730/
https://www.ncbi.nlm.nih.gov/pubmed/35674553
http://dx.doi.org/10.1590/0037-8682-0016-2022
Descripción
Sumario:BACKGROUND: The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant. METHODS: Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant. RESULTS: Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria. CONCLUSIONS: This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.

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