Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage

BACKGROUND: The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant. METHODS: A...

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Autores principales: Kontogianni, Konstantina, Bengey, Daisy, Wooding, Dominic, Buist, Kate, Greenland-Bews, Caitlin, Williams, Christopher Thomas, de Vos, Margaretha, Santos, Victor Santana, Escadafal, Camille, Adams, Emily Rebecca, Edwards, Thomas, Cubas-Atienzar, Ana Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176730/
https://www.ncbi.nlm.nih.gov/pubmed/35674553
http://dx.doi.org/10.1590/0037-8682-0016-2022
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author Kontogianni, Konstantina
Bengey, Daisy
Wooding, Dominic
Buist, Kate
Greenland-Bews, Caitlin
Williams, Christopher Thomas
de Vos, Margaretha
Santos, Victor Santana
Escadafal, Camille
Adams, Emily Rebecca
Edwards, Thomas
Cubas-Atienzar, Ana Isabel
author_facet Kontogianni, Konstantina
Bengey, Daisy
Wooding, Dominic
Buist, Kate
Greenland-Bews, Caitlin
Williams, Christopher Thomas
de Vos, Margaretha
Santos, Victor Santana
Escadafal, Camille
Adams, Emily Rebecca
Edwards, Thomas
Cubas-Atienzar, Ana Isabel
author_sort Kontogianni, Konstantina
collection PubMed
description BACKGROUND: The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant. METHODS: Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant. RESULTS: Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria. CONCLUSIONS: This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC.
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spelling pubmed-91767302022-06-17 Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage Kontogianni, Konstantina Bengey, Daisy Wooding, Dominic Buist, Kate Greenland-Bews, Caitlin Williams, Christopher Thomas de Vos, Margaretha Santos, Victor Santana Escadafal, Camille Adams, Emily Rebecca Edwards, Thomas Cubas-Atienzar, Ana Isabel Rev Soc Bras Med Trop Short Communication BACKGROUND: The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant. METHODS: Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant. RESULTS: Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria. CONCLUSIONS: This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC. Sociedade Brasileira de Medicina Tropical - SBMT 2022-06-06 /pmc/articles/PMC9176730/ /pubmed/35674553 http://dx.doi.org/10.1590/0037-8682-0016-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Kontogianni, Konstantina
Bengey, Daisy
Wooding, Dominic
Buist, Kate
Greenland-Bews, Caitlin
Williams, Christopher Thomas
de Vos, Margaretha
Santos, Victor Santana
Escadafal, Camille
Adams, Emily Rebecca
Edwards, Thomas
Cubas-Atienzar, Ana Isabel
Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage
title Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage
title_full Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage
title_fullStr Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage
title_full_unstemmed Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage
title_short Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage
title_sort analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the sars-cov-2 gamma lineage
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176730/
https://www.ncbi.nlm.nih.gov/pubmed/35674553
http://dx.doi.org/10.1590/0037-8682-0016-2022
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