IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

Tumor-associated lymphatic vessels promote metastasis and regulate antitumor immune responses. Here, we assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response. Interferon-γ (IFN-γ) released by effector T cells enha...

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Detalles Bibliográficos
Autores principales: Garnier, Laure, Pick, Robert, Montorfani, Julien, Sun, Mengzhu, Brighouse, Dale, Liaudet, Nicolas, Kammertoens, Thomas, Blankenstein, Thomas, Page, Nicolas, Bernier-Latamani, Jeremiah, Tran, Ngoc Lan, Petrova, Tatiana V., Merkler, Doron, Scheiermann, Christoph, Hugues, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176743/
https://www.ncbi.nlm.nih.gov/pubmed/35675399
http://dx.doi.org/10.1126/sciadv.abl5162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176743/
https://www.ncbi.nlm.nih.gov/pubmed/35675399
http://dx.doi.org/10.1126/sciadv.abl5162

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