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Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis

Spatiotemporal patterns of gene expression are instrumental to morphogenesis. A stable pattern interface, often between reciprocal-inhibiting morphogens, must be robustly maintained after initial patterning cues diminish, organ growth, or organ geometry changes. In plants, floral and leaf primordia...

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Autores principales: Guan, Chunmei, Qiao, Lingxia, Xiong, Yuanyuan, Zhang, Lei, Jiao, Yuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176745/
https://www.ncbi.nlm.nih.gov/pubmed/35675392
http://dx.doi.org/10.1126/sciadv.abn0368
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author Guan, Chunmei
Qiao, Lingxia
Xiong, Yuanyuan
Zhang, Lei
Jiao, Yuling
author_facet Guan, Chunmei
Qiao, Lingxia
Xiong, Yuanyuan
Zhang, Lei
Jiao, Yuling
author_sort Guan, Chunmei
collection PubMed
description Spatiotemporal patterns of gene expression are instrumental to morphogenesis. A stable pattern interface, often between reciprocal-inhibiting morphogens, must be robustly maintained after initial patterning cues diminish, organ growth, or organ geometry changes. In plants, floral and leaf primordia obtain the adaxial-abaxial pattern at the shoot apical meristem periphery. However, it is unknown how the pattern is maintained after primordia have left the shoot apex. Here, through a combination of computational simulations, time-lapse imaging, and genetic analysis, we propose a model in which auxin simultaneously promotes both adaxial and abaxial domains of expression. Furthermore, we identified multilevel feedback regulation of auxin signaling to refine the spatiotemporal patterns. Our results demonstrate that coactivation by auxin determines and stabilizes antagonistic adaxial-abaxial patterning during aerial organ formation.
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spelling pubmed-91767452022-06-17 Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis Guan, Chunmei Qiao, Lingxia Xiong, Yuanyuan Zhang, Lei Jiao, Yuling Sci Adv Biomedicine and Life Sciences Spatiotemporal patterns of gene expression are instrumental to morphogenesis. A stable pattern interface, often between reciprocal-inhibiting morphogens, must be robustly maintained after initial patterning cues diminish, organ growth, or organ geometry changes. In plants, floral and leaf primordia obtain the adaxial-abaxial pattern at the shoot apical meristem periphery. However, it is unknown how the pattern is maintained after primordia have left the shoot apex. Here, through a combination of computational simulations, time-lapse imaging, and genetic analysis, we propose a model in which auxin simultaneously promotes both adaxial and abaxial domains of expression. Furthermore, we identified multilevel feedback regulation of auxin signaling to refine the spatiotemporal patterns. Our results demonstrate that coactivation by auxin determines and stabilizes antagonistic adaxial-abaxial patterning during aerial organ formation. American Association for the Advancement of Science 2022-06-08 /pmc/articles/PMC9176745/ /pubmed/35675392 http://dx.doi.org/10.1126/sciadv.abn0368 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Guan, Chunmei
Qiao, Lingxia
Xiong, Yuanyuan
Zhang, Lei
Jiao, Yuling
Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
title Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
title_full Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
title_fullStr Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
title_full_unstemmed Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
title_short Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
title_sort coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176745/
https://www.ncbi.nlm.nih.gov/pubmed/35675392
http://dx.doi.org/10.1126/sciadv.abn0368
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