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Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
AIM: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco. METHODS: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Ot...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Iuliu Hatieganu University of Medicine and Pharmacy
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177085/ https://www.ncbi.nlm.nih.gov/pubmed/35720246 http://dx.doi.org/10.15386/mpr-2082 |
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author | Yafout, Mohamed Elhorr, Hicham Otmani, Ibrahim Sbai El Khayati, Youssef |
author_facet | Yafout, Mohamed Elhorr, Hicham Otmani, Ibrahim Sbai El Khayati, Youssef |
author_sort | Yafout, Mohamed |
collection | PubMed |
description | AIM: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco. METHODS: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Other properties such as price and sodium content were also studied. RESULTS: All the tested brands met the minimal requirement of 5 mEq. However, Aluminum hydroxide/Magnesium hydroxide combinations showed a superior acid-neutralizing capacity over other products and oral suspensions showed better results compared to other pharmaceutical forms. Regarding the cost of antacids, Aluminum hydroxide/Magnesium hydroxide combinations and calcium carbonate/magnesium carbonate combinations showed the most favorable ANC/price ratio. Some of the antacids studied contain a high amount of sodium. CONCLUSION: All the antacids marketed in Morocco meet the USP requirement regarding their ANC. However, the ANC value should be included in the antacids’ labels so that both patients and physicians can choose the most appropriate product. The ANC value should be evaluated according to the dose of the active substance instead of the minimum labeled dosage in order to allow a better result interpretation. |
format | Online Article Text |
id | pubmed-9177085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Iuliu Hatieganu University of Medicine and Pharmacy |
record_format | MEDLINE/PubMed |
spelling | pubmed-91770852022-06-17 Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco Yafout, Mohamed Elhorr, Hicham Otmani, Ibrahim Sbai El Khayati, Youssef Med Pharm Rep Original Research AIM: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco. METHODS: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Other properties such as price and sodium content were also studied. RESULTS: All the tested brands met the minimal requirement of 5 mEq. However, Aluminum hydroxide/Magnesium hydroxide combinations showed a superior acid-neutralizing capacity over other products and oral suspensions showed better results compared to other pharmaceutical forms. Regarding the cost of antacids, Aluminum hydroxide/Magnesium hydroxide combinations and calcium carbonate/magnesium carbonate combinations showed the most favorable ANC/price ratio. Some of the antacids studied contain a high amount of sodium. CONCLUSION: All the antacids marketed in Morocco meet the USP requirement regarding their ANC. However, the ANC value should be included in the antacids’ labels so that both patients and physicians can choose the most appropriate product. The ANC value should be evaluated according to the dose of the active substance instead of the minimum labeled dosage in order to allow a better result interpretation. Iuliu Hatieganu University of Medicine and Pharmacy 2022-01 2022-01-31 /pmc/articles/PMC9177085/ /pubmed/35720246 http://dx.doi.org/10.15386/mpr-2082 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License |
spellingShingle | Original Research Yafout, Mohamed Elhorr, Hicham Otmani, Ibrahim Sbai El Khayati, Youssef Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco |
title | Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco |
title_full | Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco |
title_fullStr | Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco |
title_full_unstemmed | Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco |
title_short | Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco |
title_sort | evaluation of the acid-neutralizing capacity and other properties of antacids marketed in morocco |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177085/ https://www.ncbi.nlm.nih.gov/pubmed/35720246 http://dx.doi.org/10.15386/mpr-2082 |
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