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Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco

AIM: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco. METHODS: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Ot...

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Autores principales: Yafout, Mohamed, Elhorr, Hicham, Otmani, Ibrahim Sbai El, Khayati, Youssef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iuliu Hatieganu University of Medicine and Pharmacy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177085/
https://www.ncbi.nlm.nih.gov/pubmed/35720246
http://dx.doi.org/10.15386/mpr-2082
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author Yafout, Mohamed
Elhorr, Hicham
Otmani, Ibrahim Sbai El
Khayati, Youssef
author_facet Yafout, Mohamed
Elhorr, Hicham
Otmani, Ibrahim Sbai El
Khayati, Youssef
author_sort Yafout, Mohamed
collection PubMed
description AIM: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco. METHODS: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Other properties such as price and sodium content were also studied. RESULTS: All the tested brands met the minimal requirement of 5 mEq. However, Aluminum hydroxide/Magnesium hydroxide combinations showed a superior acid-neutralizing capacity over other products and oral suspensions showed better results compared to other pharmaceutical forms. Regarding the cost of antacids, Aluminum hydroxide/Magnesium hydroxide combinations and calcium carbonate/magnesium carbonate combinations showed the most favorable ANC/price ratio. Some of the antacids studied contain a high amount of sodium. CONCLUSION: All the antacids marketed in Morocco meet the USP requirement regarding their ANC. However, the ANC value should be included in the antacids’ labels so that both patients and physicians can choose the most appropriate product. The ANC value should be evaluated according to the dose of the active substance instead of the minimum labeled dosage in order to allow a better result interpretation.
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spelling pubmed-91770852022-06-17 Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco Yafout, Mohamed Elhorr, Hicham Otmani, Ibrahim Sbai El Khayati, Youssef Med Pharm Rep Original Research AIM: The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco. METHODS: Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Other properties such as price and sodium content were also studied. RESULTS: All the tested brands met the minimal requirement of 5 mEq. However, Aluminum hydroxide/Magnesium hydroxide combinations showed a superior acid-neutralizing capacity over other products and oral suspensions showed better results compared to other pharmaceutical forms. Regarding the cost of antacids, Aluminum hydroxide/Magnesium hydroxide combinations and calcium carbonate/magnesium carbonate combinations showed the most favorable ANC/price ratio. Some of the antacids studied contain a high amount of sodium. CONCLUSION: All the antacids marketed in Morocco meet the USP requirement regarding their ANC. However, the ANC value should be included in the antacids’ labels so that both patients and physicians can choose the most appropriate product. The ANC value should be evaluated according to the dose of the active substance instead of the minimum labeled dosage in order to allow a better result interpretation. Iuliu Hatieganu University of Medicine and Pharmacy 2022-01 2022-01-31 /pmc/articles/PMC9177085/ /pubmed/35720246 http://dx.doi.org/10.15386/mpr-2082 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
spellingShingle Original Research
Yafout, Mohamed
Elhorr, Hicham
Otmani, Ibrahim Sbai El
Khayati, Youssef
Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
title Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
title_full Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
title_fullStr Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
title_full_unstemmed Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
title_short Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco
title_sort evaluation of the acid-neutralizing capacity and other properties of antacids marketed in morocco
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177085/
https://www.ncbi.nlm.nih.gov/pubmed/35720246
http://dx.doi.org/10.15386/mpr-2082
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