Cargando…

Immune-Desert Tumor Microenvironment in Thoracic SMARCA4-Deficient Undifferentiated Tumors with Limited Efficacy of Immune Checkpoint Inhibitors

BACKGROUND: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) are aggressive neoplasms. Data linking BAF alterations with tumor microenvironment (TME) and efficacy of immune checkpoint inhibitors (ICI) are contradictory. The TME of SMARCA4-UT and their response to ICI are unknown. MATE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gantzer, Justine, Davidson, Guillaume, Vokshi, Bujamin, Weingertner, Noëlle, Bougoüin, Antoine, Moreira, Marco, Lindner, Véronique, Lacroix, Guillaume, Mascaux, Céline, Chenard, Marie-Pierre, Bertucci, François, Davidson, Irwin, Kurtz, Jean-Emmanuel, Sautès-Fridman, Catherine, Fridman, Wolf H, Malouf, Gabriel G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Sarcomas
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177113/ https://www.ncbi.nlm.nih.gov/pubmed/35278076 http://dx.doi.org/10.1093/oncolo/oyac040

Ejemplares similares

Defining Tumor Rupture in Gastrointestinal Stromal Tumor
por: Nishida, Toshirou, et al.
Publicado: (2019)

Giant Cell Tumor of Bone: Effect of Longer Dosing Intervals of Denosumab on Tumor Control and Bone-related Complications
por: Jiang, Cindy Y, et al.
Publicado: (2022)

Molecular Advances in the Treatment of Advanced Gastrointestinal Stromal Tumor
por: Venkataraman, Vinayak, et al.
Publicado: (2023)

The Landmark Series: Systemic Therapy for Resectable Gastrointestinal Stromal Tumors
por: Keung, Emily Z., et al.
Publicado: (2020)

Clinical Activity of Pazopanib in Patients with Advanced Desmoplastic Small Round Cell Tumor
por: Menegaz, Brian A., et al.
Publicado: (2017)

Saving the hand: Role of multimodality therapy for Ewing's sarcoma family tumor of the palm
por: Joseph, Sanjay A., et al.
Publicado: (2018)

Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach
por: Hølmebakk, Toto, et al.
Publicado: (2021)

Desmoid Tumors in Familial Adenomatous Polyposis Patients: Favorable Outcomes with Multidisciplinary Management
por: Al-Sukhni, Eisar, et al.
Publicado: (2023)

Pexidartinib Long‐Term Hepatic Safety Profile in Patients with Tenosynovial Giant Cell Tumors
por: Lewis, James H., et al.
Publicado: (2020)

Clinical Benefit of Ripretinib Dose Escalation After Disease Progression in Advanced Gastrointestinal Stromal Tumor: An Analysis of the INVICTUS Study
por: Zalcberg, John R., et al.
Publicado: (2021)

Role of Resection Following Focal Progression with Standard Doses of Imatinib in Patients with Advanced Gastrointestinal Stromal Tumors: Results of Propensity Score Analyses
por: Cho, Hyungwoo, et al.
Publicado: (2019)

Tenosynovial Giant Cell Tumor Observational Platform Project (TOPP) Registry: A 2-Year Analysis of Patient-Reported Outcomes and Treatment Strategies
por: Palmerini, Emanuela, et al.
Publicado: (2023)

The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies
por: Petitprez, Florent, et al.
Publicado: (2020)

Thoracic SMARCA4-deficient undifferentiated tumor
por: Jiang, Jiapeng, et al.
Publicado: (2023)

Early symptoms of bone and soft tissue sarcomas: could they be diagnosed earlier?
por: George, A, et al.
Publicado: (2012)

Feasibility and Efficacy of Microwave Ablation Combined with Iodine‐125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience
por: Lu, Mingjian, et al.
Publicado: (2017)

MRI Radiomic Features Are Independently Associated With Overall Survival in Soft Tissue Sarcoma
por: Spraker, Matthew B., et al.
Publicado: (2019)

Efficacy of Trabectedin in Patients with Advanced Translocation‐Related Sarcomas: Pooled Analysis of Two Phase II Studies
por: Takahashi, Mitsuru, et al.
Publicado: (2017)

Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID‐19 Pandemic
por: Martin‐Broto, Javier, et al.
Publicado: (2020)

Single‐Center Experience with Ifosfamide Monotherapy as Second‐Line Treatment of Recurrent/Metastatic Osteosarcoma
por: Verschoor, Arie Jan, et al.
Publicado: (2019)

Primary Angiosarcoma—A Rare Cause of Right Ventricular Outflow Tract Obstruction: Case Report and Literature Review
por: Omair, Mohammad, et al.
Publicado: (2019)

Atrial Thrombus Mimicking Ewing's Sarcoma
por: Hon, Matthew, et al.
Publicado: (2019)

Neoadjuvant Chemoradiation Compared With Neoadjuvant Radiation Alone in the Management of High-Grade Soft Tissue Extremity Sarcomas
por: Hazell, Sarah Z., et al.
Publicado: (2019)

First-In-Human Phase 1 Study of a Nonwoven Fabric Bioabsorbable Spacer for Particle Therapy: Space-Making Particle Therapy (SMPT)
por: Sasaki, Ryohei, et al.
Publicado: (2019)

Functional Outcome Measurement in Patients with Lower-Extremity Soft Tissue Sarcoma: A Systematic Literature Review
por: Kask, Gilber, et al.
Publicado: (2019)

Soft Tissue Sarcoma of Lower Extremity: Functional Outcome and Quality of Life
por: Kask, Gilber, et al.
Publicado: (2021)

Percutaneous Cementoplasty for the Pelvis in Bone Metastasis: 12-Year Experience
por: Park, Jong Woong, et al.
Publicado: (2021)

Management of Soft Tissue Sarcomas in Extremities: Variation in Treatment Recommendations and Surveillance According to Specialty and Continent
por: Acem, Ibtissam, et al.
Publicado: (2021)

Late Local Recurrence and Metastasis in Soft Tissue Sarcoma of the Extremities and Trunk Wall: Better Outcome After Treatment of Late Events Compared with Early
por: von Konow, Arvid, et al.
Publicado: (2021)

Frailty in Very Elderly Patients is Not Associated with Adverse Surgical or Oncological Outcomes in Extremity Surgery for Soft Tissue Sarcoma
por: Sivarajah, Gausihi, et al.
Publicado: (2022)

Histiocytic and Dendritic Cell Sarcomas of Hematopoietic Origin Share Targetable Genomic Alterations Distinct from Follicular Dendritic Cell Sarcoma
por: Massoth, Lucas R., et al.
Publicado: (2021)

Anlotinib, Vincristine, and Irinotecan for Advanced Ewing Sarcoma After Failure of Standard Multimodal Therapy: A Two‐Cohort, Phase Ib/II Trial
por: Xu, Jie, et al.
Publicado: (2021)

Phase II Study of Cabozantinib in Patients With Bone Metastasis
por: Choy, Edwin, et al.
Publicado: (2022)

Functional Outcome Following Proximal Tibial Osteosarcoma Resection and Reconstruction by Modular Endoprosthesis
por: Ebeid, Walid Atef, et al.
Publicado: (2022)

Unplanned Excision of Soft Tissue Sarcomas of the Extremities in a Low-to-Middle-Income Country
por: Wang, Edward H. M., et al.
Publicado: (2023)

Patterns of Metastatic Recurrence of Genetically Confirmed Myxoid Liposarcoma
por: Homsy, Pauliina, et al.
Publicado: (2023)

Efficacy and Safety of Adjuvant Radiotherapy in Re-excised Soft-tissue Sarcoma After Unplanned Resection
por: Allignet, Benoît, et al.
Publicado: (2023)

Functional and Oncological Outcome of Patients with Distal Femoral Osteosarcoma Managed by Limb Salvage Using Modular Endoprosthesis
por: Sadek, Wael Mohamed Safwat, et al.
Publicado: (2023)

The Importance of Awaiting Biopsy Results in Solitary Pathological Proximal Femoral Fractures: Do We Need to Biopsy Solitary Pathological Fractures?
por: Verspoor, Floortje G. M., et al.
Publicado: (2023)

Emerging Trends in Immunotherapy for Adult Sarcomas
por: Husain, Marium, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_alkbmjq3r2654fgo9oo1d7e58j