Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review

We herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral pred...

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Autores principales: Shonai, Takuto, Kimura, Fumihiko, Watanabe, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177350/
https://www.ncbi.nlm.nih.gov/pubmed/35314552
http://dx.doi.org/10.2169/internalmedicine.9177-21
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author Shonai, Takuto
Kimura, Fumihiko
Watanabe, Junichi
author_facet Shonai, Takuto
Kimura, Fumihiko
Watanabe, Junichi
author_sort Shonai, Takuto
collection PubMed
description We herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral prednisolone therapy. A 34-year-old Japanese woman had generalized purpura after COVID-19 vaccination. Her platelet count improved rapidly after treatment with prednisolone and eltrombopag. The occurrence of two cases of ITP after COVID-19 vaccination at a single institution suggests that there could be more such undiagnosed cases, especially cases of mild secondary ITP.
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spelling pubmed-91773502022-07-05 Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review Shonai, Takuto Kimura, Fumihiko Watanabe, Junichi Intern Med Case Report We herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral prednisolone therapy. A 34-year-old Japanese woman had generalized purpura after COVID-19 vaccination. Her platelet count improved rapidly after treatment with prednisolone and eltrombopag. The occurrence of two cases of ITP after COVID-19 vaccination at a single institution suggests that there could be more such undiagnosed cases, especially cases of mild secondary ITP. The Japanese Society of Internal Medicine 2022-03-19 2022-05-15 /pmc/articles/PMC9177350/ /pubmed/35314552 http://dx.doi.org/10.2169/internalmedicine.9177-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shonai, Takuto
Kimura, Fumihiko
Watanabe, Junichi
Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
title Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
title_full Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
title_fullStr Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
title_full_unstemmed Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
title_short Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
title_sort severe immune thrombocytopenia after covid-19 vaccination: two case reports and a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177350/
https://www.ncbi.nlm.nih.gov/pubmed/35314552
http://dx.doi.org/10.2169/internalmedicine.9177-21
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AT watanabejunichi severeimmunethrombocytopeniaaftercovid19vaccinationtwocasereportsandaliteraturereview

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