Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir

A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5′-untranslated region-core region sequence revealed infection with HC...

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Autores principales: Hatanaka, Takeshi, Kakizaki, Satoru, Kaburagi, Takuya, Saito, Naoto, Nakano, Sachi, Hazama, Yoichi, Yoshida, Sachiko, Hachisu, Yoko, Tanaka, Yoshiki, Yoshinaga, Teruo, Kashiwabara, Kenji, Naganuma, Atsushi, Yamazaki, Yuichi, Uraoka, Toshio, Nagashima, Shigeo, Takahashi, Masaharu, Nishizawa, Tsutomu, Murata, Kazumoto, Okamoto, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177357/
https://www.ncbi.nlm.nih.gov/pubmed/34897154
http://dx.doi.org/10.2169/internalmedicine.8673-21
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author Hatanaka, Takeshi
Kakizaki, Satoru
Kaburagi, Takuya
Saito, Naoto
Nakano, Sachi
Hazama, Yoichi
Yoshida, Sachiko
Hachisu, Yoko
Tanaka, Yoshiki
Yoshinaga, Teruo
Kashiwabara, Kenji
Naganuma, Atsushi
Yamazaki, Yuichi
Uraoka, Toshio
Nagashima, Shigeo
Takahashi, Masaharu
Nishizawa, Tsutomu
Murata, Kazumoto
Okamoto, Hiroaki
author_facet Hatanaka, Takeshi
Kakizaki, Satoru
Kaburagi, Takuya
Saito, Naoto
Nakano, Sachi
Hazama, Yoichi
Yoshida, Sachiko
Hachisu, Yoko
Tanaka, Yoshiki
Yoshinaga, Teruo
Kashiwabara, Kenji
Naganuma, Atsushi
Yamazaki, Yuichi
Uraoka, Toshio
Nagashima, Shigeo
Takahashi, Masaharu
Nishizawa, Tsutomu
Murata, Kazumoto
Okamoto, Hiroaki
author_sort Hatanaka, Takeshi
collection PubMed
description A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5′-untranslated region-core region sequence revealed infection with HCV subtype 1g. A phylogenetic analysis of the full-length HCV genome confirmed that the patient's HCV was subtype 1g, which was the first case identified in Japan. Although his HCV possessed several naturally occurring resistance-associated substitutions in the nonstructural (NS)3 and NS5A regions, he was successfully treated by combination therapy with glecaprevir/pibrentasvir.
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spelling pubmed-91773572022-07-05 Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir Hatanaka, Takeshi Kakizaki, Satoru Kaburagi, Takuya Saito, Naoto Nakano, Sachi Hazama, Yoichi Yoshida, Sachiko Hachisu, Yoko Tanaka, Yoshiki Yoshinaga, Teruo Kashiwabara, Kenji Naganuma, Atsushi Yamazaki, Yuichi Uraoka, Toshio Nagashima, Shigeo Takahashi, Masaharu Nishizawa, Tsutomu Murata, Kazumoto Okamoto, Hiroaki Intern Med Case Report A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5′-untranslated region-core region sequence revealed infection with HCV subtype 1g. A phylogenetic analysis of the full-length HCV genome confirmed that the patient's HCV was subtype 1g, which was the first case identified in Japan. Although his HCV possessed several naturally occurring resistance-associated substitutions in the nonstructural (NS)3 and NS5A regions, he was successfully treated by combination therapy with glecaprevir/pibrentasvir. The Japanese Society of Internal Medicine 2021-12-11 2022-05-15 /pmc/articles/PMC9177357/ /pubmed/34897154 http://dx.doi.org/10.2169/internalmedicine.8673-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hatanaka, Takeshi
Kakizaki, Satoru
Kaburagi, Takuya
Saito, Naoto
Nakano, Sachi
Hazama, Yoichi
Yoshida, Sachiko
Hachisu, Yoko
Tanaka, Yoshiki
Yoshinaga, Teruo
Kashiwabara, Kenji
Naganuma, Atsushi
Yamazaki, Yuichi
Uraoka, Toshio
Nagashima, Shigeo
Takahashi, Masaharu
Nishizawa, Tsutomu
Murata, Kazumoto
Okamoto, Hiroaki
Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir
title Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir
title_full Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir
title_fullStr Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir
title_full_unstemmed Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir
title_short Chronic Infection with Hepatitis C Virus Subtype 1g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir
title_sort chronic infection with hepatitis c virus subtype 1g in a japanese patient successfully treated with glecaprevir/pibrentasvir
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177357/
https://www.ncbi.nlm.nih.gov/pubmed/34897154
http://dx.doi.org/10.2169/internalmedicine.8673-21
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