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Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor
Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), significantly reduces mortality and morbidity in patients with chronic heart failure with a reduced ejection fraction (HFrEF). However, a considerable number of patients treated with sacubitril/valsartan experience hypotensio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177371/ https://www.ncbi.nlm.nih.gov/pubmed/34707049 http://dx.doi.org/10.2169/internalmedicine.8373-21 |
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author | Kim, Moo Jun Jang, Ha Nee Song, Haa-Na Lee, Jong Sil Kang, Min Gyu |
author_facet | Kim, Moo Jun Jang, Ha Nee Song, Haa-Na Lee, Jong Sil Kang, Min Gyu |
author_sort | Kim, Moo Jun |
collection | PubMed |
description | Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), significantly reduces mortality and morbidity in patients with chronic heart failure with a reduced ejection fraction (HFrEF). However, a considerable number of patients treated with sacubitril/valsartan experience hypotension, oliguria, progressive azotemia, and renal failure as adverse events. These issues have been linked to significant gaps in the usage and dosing of guideline-directed medical therapy with ARNI in patients with HFrEF. We herein report a relevant case of pathologically proven acute tubular necrosis after the first dose of sacubitril/valsartan, highlighting the importance of optimizing the medical therapy in an outpatient with HFrEF. |
format | Online Article Text |
id | pubmed-9177371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-91773712022-07-05 Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor Kim, Moo Jun Jang, Ha Nee Song, Haa-Na Lee, Jong Sil Kang, Min Gyu Intern Med Case Report Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), significantly reduces mortality and morbidity in patients with chronic heart failure with a reduced ejection fraction (HFrEF). However, a considerable number of patients treated with sacubitril/valsartan experience hypotension, oliguria, progressive azotemia, and renal failure as adverse events. These issues have been linked to significant gaps in the usage and dosing of guideline-directed medical therapy with ARNI in patients with HFrEF. We herein report a relevant case of pathologically proven acute tubular necrosis after the first dose of sacubitril/valsartan, highlighting the importance of optimizing the medical therapy in an outpatient with HFrEF. The Japanese Society of Internal Medicine 2021-10-26 2022-05-15 /pmc/articles/PMC9177371/ /pubmed/34707049 http://dx.doi.org/10.2169/internalmedicine.8373-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kim, Moo Jun Jang, Ha Nee Song, Haa-Na Lee, Jong Sil Kang, Min Gyu Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor |
title | Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor |
title_full | Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor |
title_fullStr | Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor |
title_full_unstemmed | Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor |
title_short | Acute Tubular Necrosis Associated with Angiotensin Receptor-neprilysin Inhibitor |
title_sort | acute tubular necrosis associated with angiotensin receptor-neprilysin inhibitor |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177371/ https://www.ncbi.nlm.nih.gov/pubmed/34707049 http://dx.doi.org/10.2169/internalmedicine.8373-21 |
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