A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation

A two-months-old, male, mixed breed cat presented with epileptic seizures. The cat was diagnosed with drug-resistant epilepsy, and died at 3-years of age. No gross lesion was found at necropsy. Histopathologically, the dentate gyrus granule cell layer of the hippocampus was irregularly arranged. Gra...

Descripción completa

Detalles Bibliográficos
Autores principales: CHAMBERS, James K., IWASAKI, Shinya, IMAMOTO, Shigeki, NAKAMOTO, Yuya, UCHIDA, Kazuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2022
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177400/
https://www.ncbi.nlm.nih.gov/pubmed/35342145
http://dx.doi.org/10.1292/jvms.22-0006
_version_ 1784722880946241536
author CHAMBERS, James K.
IWASAKI, Shinya
IMAMOTO, Shigeki
NAKAMOTO, Yuya
UCHIDA, Kazuyuki
author_facet CHAMBERS, James K.
IWASAKI, Shinya
IMAMOTO, Shigeki
NAKAMOTO, Yuya
UCHIDA, Kazuyuki
author_sort CHAMBERS, James K.
collection PubMed
description A two-months-old, male, mixed breed cat presented with epileptic seizures. The cat was diagnosed with drug-resistant epilepsy, and died at 3-years of age. No gross lesion was found at necropsy. Histopathologically, the dentate gyrus granule cell layer of the hippocampus was irregularly arranged. Granule cells were dispersed and ectopic cells were sporadically observed in the molecular layer. The granule cells had an enlarged cytoplasm and swollen nucleus. Immunohistochemistry for NeuN and GFAP confirmed severe neuronal loss and mild gliosis in CA1. Binucleation and ischemic change were observed in the remaining pyramidal cells. This report describes a case of feline temporal lobe epilepsy and hippocampal sclerosis associated with dentate gyrus malformation.
format Online
Article
Text
id pubmed-9177400
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Japanese Society of Veterinary Science
record_format MEDLINE/PubMed
spelling pubmed-91774002022-06-13 A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation CHAMBERS, James K. IWASAKI, Shinya IMAMOTO, Shigeki NAKAMOTO, Yuya UCHIDA, Kazuyuki J Vet Med Sci Pathology A two-months-old, male, mixed breed cat presented with epileptic seizures. The cat was diagnosed with drug-resistant epilepsy, and died at 3-years of age. No gross lesion was found at necropsy. Histopathologically, the dentate gyrus granule cell layer of the hippocampus was irregularly arranged. Granule cells were dispersed and ectopic cells were sporadically observed in the molecular layer. The granule cells had an enlarged cytoplasm and swollen nucleus. Immunohistochemistry for NeuN and GFAP confirmed severe neuronal loss and mild gliosis in CA1. Binucleation and ischemic change were observed in the remaining pyramidal cells. This report describes a case of feline temporal lobe epilepsy and hippocampal sclerosis associated with dentate gyrus malformation. The Japanese Society of Veterinary Science 2022-03-25 2022-05 /pmc/articles/PMC9177400/ /pubmed/35342145 http://dx.doi.org/10.1292/jvms.22-0006 Text en ©2022 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
CHAMBERS, James K.
IWASAKI, Shinya
IMAMOTO, Shigeki
NAKAMOTO, Yuya
UCHIDA, Kazuyuki
A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
title A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
title_full A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
title_fullStr A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
title_full_unstemmed A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
title_short A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
title_sort case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177400/
https://www.ncbi.nlm.nih.gov/pubmed/35342145
http://dx.doi.org/10.1292/jvms.22-0006
work_keys_str_mv AT chambersjamesk acaseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT iwasakishinya acaseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT imamotoshigeki acaseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT nakamotoyuya acaseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT uchidakazuyuki acaseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT chambersjamesk caseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT iwasakishinya caseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT imamotoshigeki caseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT nakamotoyuya caseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation
AT uchidakazuyuki caseoffelinetemporallobeepilepsywithhippocampalsclerosisanddentategyrusmalformation

Ejemplares similares