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Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue

BACKGROUND: The taste of oral liquid dosage forms is a crucial factor that impacts pediatric patient compliance. Taste of suspensions can be typically evaluated by human volunteers. Recently, the electronic tongue (ET) has been proven as an emerging tool that could be useful to follow up various for...

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Autores principales: Naser Zaid, Abdel, Al Ramahi, Rowa, AlKilany, Alaaldin, Abu-Khalaf, Nawaf, El Kharouf, Maher, Abu Dayeh, Dana, Al-omari, Leena, Yaqoup, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177456/
https://www.ncbi.nlm.nih.gov/pubmed/35693442
http://dx.doi.org/10.1016/j.jsps.2022.02.016
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author Naser Zaid, Abdel
Al Ramahi, Rowa
AlKilany, Alaaldin
Abu-Khalaf, Nawaf
El Kharouf, Maher
Abu Dayeh, Dana
Al-omari, Leena
Yaqoup, Mohammad
author_facet Naser Zaid, Abdel
Al Ramahi, Rowa
AlKilany, Alaaldin
Abu-Khalaf, Nawaf
El Kharouf, Maher
Abu Dayeh, Dana
Al-omari, Leena
Yaqoup, Mohammad
author_sort Naser Zaid, Abdel
collection PubMed
description BACKGROUND: The taste of oral liquid dosage forms is a crucial factor that impacts pediatric patient compliance. Taste of suspensions can be typically evaluated by human volunteers. Recently, the electronic tongue (ET) has been proven as an emerging tool that could be useful to follow up various formulations’ properties like taste and composition. This study aimed to evaluate the potential use of ET in assessing the taste deterioration of reconstituted oral suspensions and compare the results obtained with the typical in vivo panel taste method. METHODS: Four commercially available brands of amoxicillin/ clavulanic acid suspensions (one brand and three generic formulations) were reconstituted and stored in refrigerator to assess their taste on a daily basis. The taste of these products was assessed using Alpha-Astree ET and the obtained results were compared with those obtained from an in vivo panel taste assessment using a hedonic panel test (the 5-point hedonic scale). RESULTS: All evaluated suspensions exhibited similar trends. ET and in vivo analysis indicated low taste scores for all evaluated suspensions immediately after reconstitution, possibly due to the incomplete dissolution of sucrose. The scores for all formulations were higher on day 2, followed by a steady state for the next two days. After that, a significant decay in the scores was observed in the fifth day for all evaluated suspensions. ET results were in excellent agreement with the results obtained via in vivo panel test method. CONCLUSION: The ET seems to be promising for testing the taste of pharmaceutical liquid preparations and evaluate possible deterioration upon storage or after reconstitution. It may provide a platform to avoid the involvement of pediatric volunteers in clinical evaluation and can be employed as a quality control tool during manufacturing.
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spelling pubmed-91774562022-06-10 Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue Naser Zaid, Abdel Al Ramahi, Rowa AlKilany, Alaaldin Abu-Khalaf, Nawaf El Kharouf, Maher Abu Dayeh, Dana Al-omari, Leena Yaqoup, Mohammad Saudi Pharm J Short Communication BACKGROUND: The taste of oral liquid dosage forms is a crucial factor that impacts pediatric patient compliance. Taste of suspensions can be typically evaluated by human volunteers. Recently, the electronic tongue (ET) has been proven as an emerging tool that could be useful to follow up various formulations’ properties like taste and composition. This study aimed to evaluate the potential use of ET in assessing the taste deterioration of reconstituted oral suspensions and compare the results obtained with the typical in vivo panel taste method. METHODS: Four commercially available brands of amoxicillin/ clavulanic acid suspensions (one brand and three generic formulations) were reconstituted and stored in refrigerator to assess their taste on a daily basis. The taste of these products was assessed using Alpha-Astree ET and the obtained results were compared with those obtained from an in vivo panel taste assessment using a hedonic panel test (the 5-point hedonic scale). RESULTS: All evaluated suspensions exhibited similar trends. ET and in vivo analysis indicated low taste scores for all evaluated suspensions immediately after reconstitution, possibly due to the incomplete dissolution of sucrose. The scores for all formulations were higher on day 2, followed by a steady state for the next two days. After that, a significant decay in the scores was observed in the fifth day for all evaluated suspensions. ET results were in excellent agreement with the results obtained via in vivo panel test method. CONCLUSION: The ET seems to be promising for testing the taste of pharmaceutical liquid preparations and evaluate possible deterioration upon storage or after reconstitution. It may provide a platform to avoid the involvement of pediatric volunteers in clinical evaluation and can be employed as a quality control tool during manufacturing. Elsevier 2022-05 2022-03-02 /pmc/articles/PMC9177456/ /pubmed/35693442 http://dx.doi.org/10.1016/j.jsps.2022.02.016 Text en © 2022 Published by Elsevier B.V. on behalf of King Saud University. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Naser Zaid, Abdel
Al Ramahi, Rowa
AlKilany, Alaaldin
Abu-Khalaf, Nawaf
El Kharouf, Maher
Abu Dayeh, Dana
Al-omari, Leena
Yaqoup, Mohammad
Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
title Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
title_full Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
title_fullStr Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
title_full_unstemmed Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
title_short Following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
title_sort following drug degradation and consequent taste deterioration of an oral reconstituted paediatric suspension during dosing interval via electronic tongue
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177456/
https://www.ncbi.nlm.nih.gov/pubmed/35693442
http://dx.doi.org/10.1016/j.jsps.2022.02.016
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