Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

Cytoplasmic recognition of microbial lipopolysaccharides (LPS) in human cells is elicited by the caspase-4 and caspase-5 noncanonical inflammasomes, which induce a form of inflammatory cell death termed pyroptosis. Here we show that LPS-mediated activation of caspase-4 also induces a stress response...

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Detalles Bibliográficos
Autores principales: Fernández-Duran, Irene, Quintanilla, Andrea, Tarrats, Núria, Birch, Jodie, Hari, Priya, Millar, Fraser R., Lagnado, Anthony B., Smer-Barreto, Vanessa, Muir, Morwenna, Brunton, Valerie G., Passos, João F., Acosta, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177556/
https://www.ncbi.nlm.nih.gov/pubmed/34916628
http://dx.doi.org/10.1038/s41418-021-00917-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177556/
https://www.ncbi.nlm.nih.gov/pubmed/34916628
http://dx.doi.org/10.1038/s41418-021-00917-6

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