Roles of exosomal circRNAs in tumour immunity and cancer progression

Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of intercellular communication and molecular transfer and play an essential role in tumour immunity....

Descripción completa

Detalles Bibliográficos
Autores principales: Tuo, Baojing, Chen, Zhuang, Dang, Qin, Chen, Chen, Zhang, Hao, Hu, Shengyun, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177590/
https://www.ncbi.nlm.nih.gov/pubmed/35676257
http://dx.doi.org/10.1038/s41419-022-04949-9
_version_ 1784722910209900544
author Tuo, Baojing
Chen, Zhuang
Dang, Qin
Chen, Chen
Zhang, Hao
Hu, Shengyun
Sun, Zhenqiang
author_facet Tuo, Baojing
Chen, Zhuang
Dang, Qin
Chen, Chen
Zhang, Hao
Hu, Shengyun
Sun, Zhenqiang
author_sort Tuo, Baojing
collection PubMed
description Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of intercellular communication and molecular transfer and play an essential role in tumour immunity. Circular RNAs (circRNAs) are a new type of noncoding RNA that are enriched within exosomes. In this review, we describe the effects of exosomal circRNAs on various immune cells and the mechanisms of these effects, including macrophages, neutrophils, T cells, and Natural killer (NK) cells. Next, we elaborate on the latest progress of exosome extraction. In addition, the function of exosomal circRNAs as a potential prognostic and drug sensitivity marker is described. We present the great promise of exosomal circRNAs in regulating tumour immunity, predicting patient outcomes, and evaluating drug efficacy.
format Online
Article
Text
id pubmed-9177590
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-91775902022-06-10 Roles of exosomal circRNAs in tumour immunity and cancer progression Tuo, Baojing Chen, Zhuang Dang, Qin Chen, Chen Zhang, Hao Hu, Shengyun Sun, Zhenqiang Cell Death Dis Review Article Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of intercellular communication and molecular transfer and play an essential role in tumour immunity. Circular RNAs (circRNAs) are a new type of noncoding RNA that are enriched within exosomes. In this review, we describe the effects of exosomal circRNAs on various immune cells and the mechanisms of these effects, including macrophages, neutrophils, T cells, and Natural killer (NK) cells. Next, we elaborate on the latest progress of exosome extraction. In addition, the function of exosomal circRNAs as a potential prognostic and drug sensitivity marker is described. We present the great promise of exosomal circRNAs in regulating tumour immunity, predicting patient outcomes, and evaluating drug efficacy. Nature Publishing Group UK 2022-06-09 /pmc/articles/PMC9177590/ /pubmed/35676257 http://dx.doi.org/10.1038/s41419-022-04949-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Tuo, Baojing
Chen, Zhuang
Dang, Qin
Chen, Chen
Zhang, Hao
Hu, Shengyun
Sun, Zhenqiang
Roles of exosomal circRNAs in tumour immunity and cancer progression
title Roles of exosomal circRNAs in tumour immunity and cancer progression
title_full Roles of exosomal circRNAs in tumour immunity and cancer progression
title_fullStr Roles of exosomal circRNAs in tumour immunity and cancer progression
title_full_unstemmed Roles of exosomal circRNAs in tumour immunity and cancer progression
title_short Roles of exosomal circRNAs in tumour immunity and cancer progression
title_sort roles of exosomal circrnas in tumour immunity and cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177590/
https://www.ncbi.nlm.nih.gov/pubmed/35676257
http://dx.doi.org/10.1038/s41419-022-04949-9
work_keys_str_mv AT tuobaojing rolesofexosomalcircrnasintumourimmunityandcancerprogression
AT chenzhuang rolesofexosomalcircrnasintumourimmunityandcancerprogression
AT dangqin rolesofexosomalcircrnasintumourimmunityandcancerprogression
AT chenchen rolesofexosomalcircrnasintumourimmunityandcancerprogression
AT zhanghao rolesofexosomalcircrnasintumourimmunityandcancerprogression
AT hushengyun rolesofexosomalcircrnasintumourimmunityandcancerprogression
AT sunzhenqiang rolesofexosomalcircrnasintumourimmunityandcancerprogression

Ejemplares similares