Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumor growth

Tumorigenesis is associated with elevated glucose and glutamine consumption, but how cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal that ammonia, released from glutamine, promotes lipogenesis via activation of sterol regulatory element-binding proteins (S...

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Detalles Bibliográficos
Autores principales: Cheng, Chunming, Geng, Feng, Li, Zoe, Zhong, Yaogang, Wang, Huabao, Cheng, Xiang, Zhao, Yue, Mo, Xiaokui, Horbinski, Craig, Duan, Wenrui, Chakravarti, Arnab, Cheng, Xiaolin, Guo, Deliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177652/
https://www.ncbi.nlm.nih.gov/pubmed/35534729
http://dx.doi.org/10.1038/s42255-022-00568-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177652/
https://www.ncbi.nlm.nih.gov/pubmed/35534729
http://dx.doi.org/10.1038/s42255-022-00568-y

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